Nat Prod Sci.
2021 Sep;27(3):183-186. 10.20307/nps.2021.27.3.183.
Melixyloidin, A New Acridone Alkaloid from Melicope xanthoxyloides Leaves
- Affiliations
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- 1Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Surabaya, Surabaya 60231, Indonesia
- 2Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia
- KMID: 2521088
- DOI: http://doi.org/10.20307/nps.2021.27.3.183
Abstract
- A new acridone alkaloid, melixyloidin (1), and two known alkaloids (2-3) were isolated from Melicope xanthoxyloides (F. Muell) T.G. Hartley leaves. The structure of melixyloidin were elucidated using NMR spectra and high-resolution ESIMS data. Acridone alkaloids 1-3 were evaluated against MCF-7 and HeLacells. 1,3,4-Trimethoxy-10-methylacridin-9-one (2) showed potent cytotoxic activity against MCF-7 cells with an IC50 value of 5.31 μM.
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