Mycobiology.  2021 Aug;49(4):434-437. 10.1080/12298093.2021.1924926.

Consoramides A–C, New Zwitterionic Alkaloids from the Fungus Irpex consors

• Kim JY
• Ki DW
• Lee YJ
• Ha LS
• Woo EE
• Lee IK
• Yun BS

• KMID: 2520576
• DOI: http://doi.org/10.1080/12298093.2021.1924926

Abstract

In our ongoing search for new secondary metabolites from fungi, a basidiomycete fungus Irpex consors was selected for mycochemical investigation, and three new zwitterionic alkaloids (1-3) and five known compounds (4-8) were isolated from the culture broth (16 l) of I. consors. The culture filtrate was fractionated by a series of column chromatography including Diaion HP-20, silica gel, and Sephadex LH-20, Sep-Pak C₁₈ cartridge, medium pressure liquid chromatography (MPLC), and high pressure liquid chromatography (HPLC) to yield eight compounds (1-8). The structures of the isolated compounds were elucidated by the interpretation of nuclear magnetic resonance (NMR) spectra and high-resolution mass spectrometry (HR-MS). Their antioxidant and antibacterial activities were examined. The zwitterionic structures of three new sesquiterpene alkaloids (1-3) were determined together with five known compounds identified as stereumamide E (4), stereumamide G (5), stereumamide H (6), stereumamide D (7), and sterostrein H (8). This is the first report of the zwitterionic alkaloids in the culture broth of I. consors. Three new zwitterionic alkaloids were named as consoramides A–C (1-3).

Keyword

Consoramides A–C; Irpex consors; NMR; Zwitterionic alkaloids