J Korean Assoc Oral Maxillofac Surg.  2021 Aug;47(4):279-285. 10.5125/jkaoms.2021.47.4.279.

Comparative evaluation of the efficacy of wound healing with and without dehydrated human amniotic/chorionic membrane in alveoloplasty: a pilot study

Affiliations
  • 1Department of Oral & Maxillofacial Surgery, Dr. D. Y. Patil Vidyapeeth, Pune, India

Abstract


Objectives
Wound healing is an integral part of any surgical procedure. Appropriate wound closure is critical to any successful surgical procedure, especially intraoral procedures. Various factors aid in wound healing, both pharmacological and non-pharmacological. Dehydrated human amniotic/ chorionic membrane (dHACM) is an emerging bioinert material that contains anti-inflammatory properties, angiogenetic properties, osteogenic potential, and various growth factors. The purpose of this study was to evaluate the efficacy of wound healing properties of dHACM in bilateral alveoloplasty patients.
Materials and Methods
A prospective split-mouth study was conducted on 10 patients. Site A received sutures with dHACM and site B was sutured without dHACM. Wound healing was assessed with the Landry, Turnbull, and Howley Index.
Results
Sites A and site B were compared. A P<0.05 and a test value of 22 was obtained, indicating a statistical difference between the two sites.
Conclusion
Our study showed better healing with dHACM than without.

Keyword

Biological dressings; Amnion; Wound Healing; Alveoloplasty

Figure

  • Fig. 1 Dehydrated human amniotic/chorionic membrane obtained from human placental extract.

  • Fig. 2 Alveoloplasty procedure done on lower jaw.

  • Fig. 3 Dehydrated human amniotic/chorionic placed after alveoloplasty procedure.

  • Fig. 4 Closure done with 3-0 silk after placement of dehydrated human amniotic/chprionic procedure.

  • Fig. 5 Demographic chart of patients.

  • Fig. 6 Comparison of healing index. Mann–Whitney U test value=22, P<0.05. There is a significant difference between the two groups. (dHACM: dehydrated human amniotic/chorionic membrane)

  • Fig. 7 Comparison of tissue color. Mann–Whitney U test value=38, P>0.05. There is no statistically significant difference between the two groups. (dHACM: dehydrated human amniotic/chorionic membrane)

  • Fig. 8 Overall comparison of healing index of soft tissues. (HA: dehydrated human amniotic/chorionic membrane).


Reference

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