Korean J Parasitol.
2021 Aug;59(4):415-419. 10.3347/kjp.2021.59.4.415.
Seroprevalence of Plasmodium vivax Circumsporozoite Protein Antibody in High-Risk Malaria Areas in Korea
- Affiliations
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- 1Department of Parasitology and Tropical Medicine & Global Resource Bank of Parasitic Protozoa Pathogens, Inha University School of Medicine, Incheon 22212, Korea
- 2Korea Health Evaluation Institute, Sahmyook University, Seoul 01795, Korea
- 3Infectious Diseases Investigation Division, Jeonnam Institute of Public Health and Environment, Muan 58568, Korea
- 4Department of Pharmacology, Inha University School of Medicine, Incheon, 22212, Korea
- 5Department of Life Sciences, Incheon National University, Incheon 22012, Korea
- 6Convergence Research Center for Insect Vectors, Incheon National University, Incheon 22012, Korea
- 7Department of Parasitology and Tropical Medicine, Department of Convergence Medical Science, and Institute of Health Sciences, Gyeongsang National University College of Medicine, Jinju 52727, Korea
- KMID: 2519816
- DOI: http://doi.org/10.3347/kjp.2021.59.4.415
Abstract
- The circumsporozoite protein (CSP) of Plasmodium spp. is a diagnostic antigen and useful biomarker for monitoring short-term/seasonal changes to malaria transmission. Using P. vivax CSP antibody ELISA, epidemiological characteristics were analyzed in the residents of Ganghwa, Cheorwon, Paju, and Goseong from 2017 to 2018. In Ganghwa and Cheorwon, 1.6% and 1.2% of residents, respectively, were PvCSP-antibody-positive in 2018, which indicates a decrease of 0.4% in the positive rate compared to 2017. The annual parasite incidence (API) in Ganghwa and Cheorwon was 24.9 and 10.5 in 2017 and 20.3 and 10.7 in 2018, respectively. Although the changes were not significant, the API in Ganghwa decreased slightly by 4.5 in 2018 compared to the previous year. In Paju and Goseong, 3.9% and 2.0% of residents were positive for the PvCSP antibody. The API in Paju was 13.1 in 2017 and 16.0 in 2018, although no malaria patients were reported for the 2 years. Therefore, the results suggest that PvCSP is a useful antigen for confirming initial malaria infection. Additionally, considering that the antibody is relatively transient, it can be employed for sero-epidemiological studies to determine the extent of malaria transmission in the current year.
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