Neonatal Med.  2021 Aug;28(3):116-123. 10.5385/nm.2021.28.3.116.

Targeting Risk Factors for the Control of Central Line-Associated Bloodstream Infection in the Neonatal Intensive Care Unit: A Single Tertiary Center Experience

• Jeong J
• Kwun Y
• Kim Mj
• Choi SH
• Jung E
• Lee BS
• Kim KS
• Kim EAR

• KMID: 2519774
• DOI: http://doi.org/10.5385/nm.2021.28.3.116

Abstract

Purpose
The aim of this study was to estimate the effect of targeting risk factors for the control of central line-associated bloodstream infection (CLABSI) among high-risk infants in a tertiary neonatal intensive care unit (NICU).
Methods
Infants admitted to the NICU and diagnosed with CLABSI from January to December 2013 were eligible for inclusion to the study. The CLABSI group (n=47) was matched in a 1:2 ratio to the control group (n=94) based on gestational age, birth weight, and Score for Neonatal Acute Physiology-II. Risk factors for CLABSI were identified using the Cox proportional hazard model, and analysis of the effect of these risk factors targeting infection control was performed.
Results
The risk factors associated with CLABSI were prolonged central line dwell days (adjusted hazard ratio [HR], 1.028; 95% confidence interval [CI], 1.011 to 1.045; P=0.001), use of a silicone catheter (adjusted HR, 5.895; 95% CI, 1.893 to 18.355; P=0.002), surgical treatment (adjusted HR, 3.793; 95% CI, 1.467 to 9.805; P=0.006), and less probiotic supplementation (adjusted HR, 0.254; 95% CI, 0.068 to 0.949; P=0.042). By targeting these risk factors with a quality improvement initiative, the mean CLABSI incidence rate per 1,000 catheter-days decreased from 6.6 to 3.1 (P=0.004).
Conclusion
Targeting risk factors for infection control significantly reduced the rate of CLABSI among high-risk infants in the NICU.

Keyword

Central venous catheter; Sepsis, neonatal; Risk factors; Neonatal intensive care unit; Quality improvement

Figure

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  Figure 1. Incidence of central line-associated bloodstream infection and central line utilization ratio between phase I and phase II.

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