Korean J Med.
2021 Aug;96(4):337-340. 10.3904/kjm.2021.96.4.337.
Interpretation of Anti-Nuclear Antibody Tests
- Affiliations
-
- 1Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea
- KMID: 2519161
- DOI: http://doi.org/10.3904/kjm.2021.96.4.337
Abstract
- Anti-nuclear antibodies (ANAs) are autoantibodies against nuclear substances or other cellular components. ANA tests are used in the diagnostic process to screen patients with suspected rheumatic or autoimmune diseases. ANA-associated diseases are characterized by a high titer of antinuclear antibodies and include systemic lupus erythematosus, systemic sclerosis, and mixed connective tissue diseases. ANA test results must be cautiously interpreted as they can be positive not only in infections and oncological diseases but also for the healthy general population. The ANA test mainly uses the indirect immunofluorescence test, and the results are expressed in terms of the final titer and pattern. The ANA test can increase diagnostic value when used in conjunction with the evaluation of disease-related clinical symptoms.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- A Study of the Standardization and the External Quality Assessment for Antinuclear Antibody, Anti-Double-Stranded DNA, and AntiExtractable Nuclear Antigen Antibody Testing
- Study on the Anti-Smooth Muscle Antibody and Anti-Nuclear Antibody of Chronic Active Hepatitis, Chronic Persistant Heratitis and Liver Cirrhosis in Korea
- Usefulness of column agglutination test for irregular antibody screening and identification
- Frequency and distribution of unexpected antibodies of Koreans
- Two Cases with Positive Ice Tests Mimicking Ocular Myasthenia Gravis
