J Korean Med Assoc.  2021 Aug;64(8):561-569. 10.5124/jkma.2021.64.8.561.

Safe and appropriate use of laxatives for colonoscopy

• Kim WS
• Lee BJ

• KMID: 2519080
• DOI: http://doi.org/10.5124/jkma.2021.64.8.561

Abstract

Background
Appropriate bowel preparation is essential for effective colonoscopy. Inadequate use of bowel preparation solutions reduces patient compliance, makes the detection of lesions such as adenoma difficult, and increases the risk of complication such as perforation.
Current Concepts
A 4-L polyethylene glycol (PEG) solution can be safely used for bowel preparation, even in most individuals with underlying diseases. However, it requires a high preparation-volume intake and has poor patient compliance due to its unpleasant taste. Therefore, a 2- or 1- L sulfate-free, PEG-based laxative was developed to, reduce the amount of PEG and improve the taste. Furthermore, simethicon-containing laxative formulation was developed to eliminate gas bubbles. In addition, oral bowel preparation solutions with enema agents and prokinetics were used to improve bowel preparation, but no improvement was observed. Various alternative laxatives are available; however, PEG-based bowel preparation solutions are still recommended in most cases due to their stability.
Discussion and Conclusion
Although a 4-L PEG solutions recommended for bowel preparation in most cases, several laxatives have been introduced to overcome its disadvantages. The laxative agent must be selected according to each patient’s specific characteristics. Moreover, the method of taking bowel preparation solutions and additional bowel preparation medications must be carefully chosen. In addition, patient education via various methods, such as using a smartphone, when taking a bowel preparation agent may help improve bowel preparation quality.

Keyword

Bowel preparation solutions; Laxatives; Colonoscopy; Polyethylene glycol; 장세척액; 완하제; 대장내시경; 폴리에틸렌글라이콜