J Rhinol.  2021 Jul;28(2):89-93. 10.18787/jr.2021.00348.

The Similarity of Biomarkers Level between Direct Nasal Fluid and Nasal Lavage Fluid in Allergic Rhinitis Patients

• Kim JS
• Han SJ
• Park JM
• Kim SW
• Eun YG
• Kwon OE

• KMID: 2518673
• DOI: http://doi.org/10.18787/jr.2021.00348

Abstract

Background and Objectives
Biomarkers of allergic rhinitis (AR) have been studied; however, little is known regarding their practical application in the diagnosis of AR. Previous studies collected samples using saline lavage, nasal brushing, or nasal biopsy. To utilize nasal fluid as a diagnostic tool, we need to standardize the method of sample collection. Therefore, this study aimed to evaluate the difference in concentration of biomarkers depending on the method of nasal fluid collection. Materials and Method: Forty-five AR patients who had greater than moderate AR symptoms and who had positive results on skin prick test and serum-specific IgE tests were enrolled in this study. Nasal fluid was collected using the direct method or saline lavage method. The concentration of each biomarker was analyzed using enzyme-linked immunosorbent assay and the values compared.
Results
Nasal fluid samples were collected directly from 14 patients and were collected via saline lavage in 31 patients. No significant differences were found in the median value of each biomarker between the two methods of nasal sample collection.
Conclusion
Nasal fluid collection method does not significantly affect biomarker concentration.

Keyword

Allergic rhinitisㆍBiomarkerㆍDiagnosis

Reference

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