Korean J Radiol.  2021 Jul;22(7):1203-1212. 10.3348/kjr.2020.1229.

Cone-Beam CT-Guided Percutaneous Transthoracic Needle Lung Biopsy of Juxtaphrenic Lesions: Diagnostic Accuracy and Complications

  • 1Department of Radiology, Seoul National University Hospital, Seoul, Korea
  • 2Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Korea
  • 3Cancer Research Institute, Seoul National University, Seoul, Korea
  • 4Institute of Medical and Biological Engineering, Medical Research Center, Seoul National University, Seoul, Korea


To investigate the diagnostic accuracy and complications of cone-beam CT-guided percutaneous transthoracic needle biopsy (PTNB) of juxtaphrenic lesions and identify the risk factors for diagnostic failure and complications.
Materials and Methods
In total, 336 PTNB procedures for lung lesions (mean size ± standard deviation [SD], 4.3 ± 2.3 cm) abutting the diaphragm in 326 patients (189 male and 137 female; mean age ± SD, 65.2 ± 11.4 years) performed between January 2010 and December 2014 were included. The accuracy, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the PTNB procedures for the diagnosis of malignancy were measured based on the intentionto-diagnose principle. The risk factors for diagnostic failures and complications were evaluated using logistic regression analysis.
The accuracy, sensitivity, specificity, PPV, and NPV were 92.7% (293/316), 91.3% (219/240), 91.4% (74/81), 96.9% (219/226), and 77.9% (74/95), respectively. There were 23 diagnostic failures (7.3%), and lesion sizes ≤ 2 cm (p = 0.045) were the only significant risk factors for diagnostic failure. Complications occurred in 98 cases (29.2%), including 89 cases of pneumothorax (26.5%) and 7 cases of hemoptysis (2.1%). The multivariable analysis showed that old age (> 65 years) (p = 0.002), lesion size of ≤ 2 cm (p = 0.003), emphysema (p = 0.006), and distance from the pleura to the target lesion (> 2 cm) (p = 0.010) were significant risk factors for complications.
The diagnostic accuracy of cone-beam CT-guided PTNB of juxtaphrenic lesions for malignancy was fairly high, and the target lesion size was the only significant predictor of diagnostic failure. Complications of cone-beam CT-guided PTNB of juxtaphrenic lesions occurred at a reasonable rate.


Lung; Biopsy; Image-guided biopsy; Cone-beam computed tomography
Full Text Links
  • KJR
export Copy
  • Twitter
  • Facebook
Similar articles
    DB Error: unknown error