Yonsei Med J.  2021 Aug;62(8):767-775. 10.3349/ymj.2021.62.8.767.

Correlation between Metal Ions and Cytokines in the Saliva of Patients with Oral Lichenoid Lesions

• Ju HM
• Yu SN
• Ahn YW
• Ok SM
• Ahn SC
• Jeong SH

• KMID: 2518575
• DOI: http://doi.org/10.3349/ymj.2021.62.8.767

Abstract

Purpose
We aimed to investigate the effect of metal ions from oral prostheses (OPs) released into the saliva of patients with oral lichenoid lesions (OLLs).
Materials and Methods
Subjects (n=183) were divided into four groups according to the presence or absence of OLL and OP. Concentrations of the metal ions titanium, chromium (Cr), cobalt (Co), nickel (Ni), palladium (Pd), silver (Ag), platinum (Pt), gold (Au), and zirconium (Zr) were measured using a laser-ablation microprobe inductively coupled to a plasma mass spectrometer. Saliva levels of interleukin (IL)-6, IL-1β, IL-8, and tumor necrosis factor-α were detected using an enzyme-linked immunosorbent assay. The reticulation/keratosis, erythema, and ulceration (REU) scoring system was used to assess the severity of OLL.
Results
Mean concentrations of IL-6 and IL-8 were statistically higher in OLL patients with OPs. The concentration of Ni was high in OLL groups. The concentrations of Cr, Ni, and Au ions in the saliva were positively correlated with IL-8. REU scores were positively correlated with salivary concentrations of IL-6 and IL-8, as well as with concentrations of Cr, Ni, and Au.
Conclusion
Increased concentrations of metal ions, especially Ni, in saliva were positively correlated with IL-8 and showed positive correlations with the severity of OLL.

Keyword

Oral lichenoid lesion; metal ion; saliva; cytokine; oral prosthesis