Anat Biol Anthropol.  2021 Jun;34(2):45-52. 10.11637/aba.2021.34.2.45.

Anti-allergic Effect of Fructus amomi on Ovalbumin-induced Asthma Mice Model

• Piao CH
• Fan YJ
• Nguyen TV
• Yu ZN
• Shin HS
• Song CH
• Chai OH

• KMID: 2518360
• DOI: http://doi.org/10.11637/aba.2021.34.2.45

Abstract

Despite studies on the anti-inflammatory effect of Fructus amomi, mature fruit of Amomum villosum Lour, have been getting increasing extensively, it remains unknown about the detailed effects of F. amomi on ovalbumin (OVA)-induced mouse asthma model. In this study, we examined the effect of F. amomi on OVA-induced asthma by analyzing Th1/Th2 cytokine production, histopathologic changes, and focusing on the NF-κB signaling. Oral administration of F. amomi reduced the number of inflammatory cells especially eosinophils and improved airway and pulmonary inflammation in the lungs of OVA-challenged mice. In addition, F. amomi significantly downregulated the overproduction of tumor necrosis factor-α, IL-1β, IL-4, IL-5 and the levels of OVA-specific both IgE and IgG1 and increased the secretion of interferon-γ and OVA-specific IgG2a. Moreover, F. amomi suppressed the increase of total NF-κB level and the phosphorylation of IκB-α and NF-κB by OVA. F. amomi may have therapeutic effect for allergic asthma by modulating Th1/Th2 cytokine imbalance and inhibiting NF-κB signaling activation.

Keyword

Frutus amomi; Asthma; Th1/Th2 cytokine imbalance; OVA-specific IgE/IgG1/IgG2; NF-κB signaling