Psychiatry Investig.  2021 Jun;18(6):545-552. 10.30773/pi.2020.0347.

Reconciliation of Two Cognitive Models in Obsessive-Compulsive Disorder: An fMRI Study

Affiliations
  • 1Department of Medical & Biological Engineering, Kyungpook National University, Daegu, Republic of Korea
  • 2Department of Psychiatry, Kyungpook National University Chilgok Hospital, Daegu, Republic of Korea
  • 3Department of Psychiatry, School of Medicine, Kyungpook National University, Daegu, Republic of Korea
  • 4Department of Molecular Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea
  • 5Department of Radiology, Kyungpook National University Hospital, Daegu, Republic of Korea
  • 6Department of Psychiatry, Kyungpook National University Hospital, Daegu, Republic of Korea

Abstract


Objective
Although cognitive models of obsessive-compulsive disorder (OCD) fall into two categories: cognitive deficit models and dysfunctional belief models, these approaches have their own ways and have hardly been reconciled. Therefore, this study aimed to investigate the potential relationships between cognitive deficit (using the Wisconsin Card Sorting Task, WCST) and dysfunctional belief (measured by scales of dysfunctional beliefs) mediated by neural activity in OCD patients.
Methods
Thirty OCD patients and 30 healthy participants performed the WCST condition and a baseline MATCH condition during the 3T-functional magnetic resonance imaging (fMRI) acquisition.
Results
Engagement of additional frontoparietal networks with poorer performance of WCST was found during the fMRI scan in OCD patients. Selected regions of interest from activated regions have positive relationships with dysfunctional beliefs and with the unacceptable thoughts symptom dimension in the OCD group.
Conclusion
Findings suggest that alteration in frontoparietal networks related to cognitive deficits can be associated with dysfunctional beliefs while performing conventional neurocognitive tasks and this association with dysfunctional beliefs may be pronounced in the unacceptable thoughts domain-dominant OCD patients.

Keyword

Cognitive deficit, Executive function, Dysfunctional beliefs, Frontoparietal network, Obsessive-compulsive symptom domain.
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