1. Boden SD, Kang J, Sandhu H, Heller JG. Use of recombinant human bone morphogenetic protein-2 to achieve posterolateral lumbar spine fusion in humans: a prospective, randomized clinical pilot trial: 2002 Volvo Award in clinical studies. Spine (Phila Pa 1976). 27:2662–2673. 2002.
Article
2. Bormann N, Schwabe P, Smith MD, Wildemann B. Analysis of parameters influencing the release of antibiotics mixed with bone grafting material using a reliable mixing procedure. Bone. 59:162–172. 2014.
Article
3. Brantigan JW, Steffee AD, Geiger JM. A carbon fiber implant to aid interbody lumbar fusion. Mechanical testing. Spine (Phila Pa 1976). 16(6 Suppl):S277–S282. 1991.
4. Brekke JH, Toth JM. Principles of tissue engineering applied to programmable osteogenesis. J Biomed Mater Res. 43:380–398. 1998.
Article
5. Burkus JK, Gornet MF, Dickman CA, Zdeblick TA. Anterior lumbar interbody fusion using rhBMP-2 with tapered interbody cages. J Spinal Disord Tech. 15:337–349. 2002.
Article
6. Carragee EJ, Chu G, Rohatgi R, Hurwitz EL, Weiner BK, Yoon ST, et al. Cancer risk after use of recombinant bone morphogenetic protein-2 for spinal arthrodesis. J Bone Joint Surg Am. 95:1537–1545. 2013.
Article
7. Chang HK, Huang M, Wu JC, Huang WC, Wang MY. Less opioid consumption with enhanced recovery after surgery transforaminal lumbar interbody fusion (TLIF): a comparison to standard minimally-invasive TLIF. Neurospine. 17:228–236. 2020.
Article
8. Chen NF, Smith ZA, Stiner E, Armin S, Sheikh H, Khoo LT. Symptomatic ectopic bone formation after off-label use of recombinant human bone morphogenetic protein-2 in transforaminal lumbar interbody fusion. J Neurosurg Spine. 12:40–46. 2010.
Article
9. Choudhry OJ, Christiano LD, Singh R, Golden BM, Liu JK. Bone morphogenetic protein-induced inflammatory cyst formation after lumbar fusion causing nerve root compression. J Neurosurg Spine. 16:296–301. 2012.
Article
10. Cooper GS, Kou TD. Risk of cancer after lumbar fusion surgery with recombinant human bone morphogenic protein-2 (rh-BMP-2). Spine (Phila Pa 1976). 38:1862–1868. 2013.
Article
11. Deutsch H. High-dose bone morphogenetic protein-induced ectopic abdomen bone growth. Spine J. 10:e1–e4. 2010.
Article
12. Epstein NE. Basic science and spine literature document bone morphogenetic protein increases cancer risk. Surg Neurol Int. 5(suppl 15):S552–S560. 2014.
Article
13. Gitelman SE, Kobrin MS, Ye JQ, Lopez AR, Lee A, Derynck R. Recombinant Vgr-1/BMP-6-expressing tumors induce fibrosis and endochondral bone formation in vivo. J Cell Biol. 126:1595–1609. 1994.
Article
14. Gruskin E, Doll BA, Futrell FW, Schmitz JP, Hollinger JO. Demineralized bone matrix in bone repair: history and use. Adv Drug Deliv Rev. 64:1063–1077. 2012.
Article
15. Guerado E, Fuerstenberg CH. What bone graft substitutes should we use in post-traumatic spinal fusion? Injury. 42 Suppl 2:S64–S71. 2011.
Article
16. Han B, Yang Z, Nimni M. Effects of moisture and temperature on the osteoinductivity of demineralized bone matrix. J Orthop Res. 23:855–861. 2005.
Article
17. Haws BE, Khechen B, Patel DV, Yoo JS, Guntin JA, Cardinal KL, et al. Impact of iliac crest bone grafting on postoperative outcomes and complication rates following minimally invasive transforaminal lumbar interbody fusion. Neurospine. 16:772–779. 2019.
Article
18. Katayama Y, Matsuyama Y, Yoshihara H, Sakai Y, Nakamura H, Imagama S, et al. Clinical and radiographic outcomes of posterolateral lumbar spine fusion in humans using recombinant human bone morphogenetic protein-2: an average five-year follow-up study. Int Orthop. 33:1061–1067. 2009.
Article
19. Kim DJ. Autogenous bone graft and bone substitutes. J Korean Soc Spine Surg. 15:54–65. 2008.
Article
20. Lad SP, Bagley JH, Karikari IO, Babu R, Ugiliweneza B, Kong M, et al. Cancer after spinal fusion: the role of bone morphogenetic protein. Neurosurgery. 73:440–449. 2013.
21. Ma GW. Posterior lumbar interbody fusion with specialized instruments. Clin Orthop Relat Res. 193:57–63. 1985.
Article
22. Massaad E, Fatima N, Kiapour A, Hadzipasic M, Shankar GM, Shin JH. Polyetheretherketone versus titanium cages for posterior lumbar interbody fusion: meta-analysis and review of the literature. Neurospine. 17:125–135. 2020.
Article
23. May RD, Frauchiger DA, Albers CE, Hofstetter W, Gantenbein B. Exogenous stimulation of human intervertebral disc cells in 3-dimensional alginate bead culture with BMP2 and L51P: cytocompatibility and effects on cell phenotype. Neurospine. 17:77–87. 2020.
Article
24. McKay WF, Peckham SM, Badura JM. A comprehensive clinical review of recombinant human bone morphogenetic protein-2 (INFUSE bone graft). Int Orthop. 31:729–734. 2007.
Article
25. Mindea SA, Shih P, Song JK. Recombinant human bone morphogenetic protein-2-induced radiculitis in elective minimally invasive transforaminal lumbar interbody fusions: a series review. Spine (Phila Pa 1976). 34:1480–1484. discussion 1485. 2009.
Article
26. Mummaneni PV, Pan J, Haid RW, Rodts GE. Contribution of recombinant human bone morphogenetic protein-2 to the rapid creation of interbody fusion when used in transforaminal lumbar interbody fusion: a preliminary report. Invited submission from the Joint Section Meeting on Disorders of the Spine and Peripheral Nerves, March 2004. J Neurosurg Spine. 1:19–23. 2004.
Article
27. Niederwanger M, Urist MR. Demineralized bone matrix supplied by bone banks for a carrier of recombinant human bone morphogenetic protein (rhBMP-2): a substitute for autogeneic bone grafts. J Oral Implantol. 22:210–215. 1996.
28. Overley SC, McAnany SJ, Anwar MA, Merrill RK, Lovy A, Guzman JZ, et al. Predictive factors and rates of fusion in minimally invasive transforaminal lumbar interbody fusion utilizing rhBMP-2 or mesenchymal stem cells. Int J Spine Surg. 13:46–52. 2019.
Article
29. Rihn JA, Patel R, Makda J, Hong J, Anderson DG, Vaccaro AR, et al. Complications associated with single-level transforaminal lumbar interbody fusion. Spine J. 9:623–629. 2009.
Article
30. Sampath TK, Maliakal JC, Hauschka PV, Jones WK, Sasak H, Tucker RF, et al. Recombinant human osteogenic protein-1 (hOP-1) induces new bone formation in vivo with a specific activity comparable with natural bovine osteogenic protein and stimulates osteoblast proliferation and differentiation in vitro. J Biol Chem. 267:20352–20362. 1992.
Article
31. Schmidmaier G, Herrmann S, Green J, Weber T, Scharfenberger A, Haas NP, et al. Quantitative assessment of growth factors in reaming aspirate, iliac crest, and platelet preparation. Bone. 39:1156–1163. 2006.
Article
32. Shahlaie K, Kim KD. Occipitocervical fusion using recombinant human bone morphogenetic protein-2: adverse effects due to tissue swelling and seroma. Spine (Phila Pa 1976). 33:2361–2366. 2008.
Article
33. Smucker JD, Rhee JM, Singh K, Yoon ST, Heller JG. Increased swelling complications associated with off-label usage of rhBMP-2 in the anterior cervical spine. Spine (Phila Pa 1976). 31:2813–2819. 2006.
Article
34. Takeda M. Experience in posterior lumbar interbody fusion: unicortical versus bicortical autologous grafts. Clin Orthop Relat Res. 193:120–126. 1985.
35. Urist MR. Bone: formation by autoinduction. Science. 150:893–899. 1965.
Article
36. Urist MR, Strates BS. Bone formation in implants of partially and wholly demineralized bone matrix. Including observations on acetone-fixed intra and extracellular proteins. Clin Orthop Relat Res. 71:271–278. 1970.
37. Villavicencio AT, Burneikiene S, Nelson EL, Bulsara KR, Favors M, Thramann J. Safety of transforaminal lumbar interbody fusion and intervertebral recombinant human bone morphogenetic protein-2. J Neurosurg Spine. 3:436–443. 2005.
Article
38. Winn SR, Uludag H, Hollinger JO. Carrier systems for bone morphogenetic proteins. Clin Orthop Relat Res. 367 Suppl:S95–S106. 1999.
Article
39. Yan L, Chang Z, He B, Liu T, Wang X, Guo H, et al. Efficacy of rhBMP-2 versus iliac crest bone graft for posterior C1-C2 fusion in patients older than 60 years. Orthopedics. 37:e51–e57. 2014.
Article