J Korean Neurosurg Soc.  2021 Jul;64(4):534-542. 10.3340/jkns.2020.0262.

Intravenous Fluid Selection for Unruptured Intracranial Aneurysm Clipping : Balanced Crystalloid versus Normal Saline

• Kang J
• Song YJ
• Jeon S
• Lee J
• Lee E
• Lee JY
• Lee E
• Bang JS
• Lee SU
• Han MK
• Oh CW
• Kim T

• KMID: 2517686
• DOI: http://doi.org/10.3340/jkns.2020.0262

Abstract

Objective
: While balanced crystalloid (BC) could be a relevant fluid regimen with buffer system compared with normal saline (NS), there have been no studies on the optimal fluid for surgery of an unruptured intracranial aneurysm (UIA). This study aimed to compare the effects of fluid regimens between NS and BC on the metabolic and clinical outcomes of patients who underwent surgery for UIA.
Methods
: This study was designed as a propensity score matched retrospective comparative study and included adult patients who underwent UIA clipping. Patient groups were categorized as NS and BC groups based on the types of pre-operative fluid and the amount of fluid administered during surgery. The primary outcomes were defined as electrolyte imbalance and acidosis immediately after surgery. The secondary outcomes were the length of stay in the intensive care unit (ICU) and duration from the end of the operation to extubation.
Results
: A total of 586 patients were enrolled in this study, with each of 293 patients assigned to the NS and BC groups, respectively. Immediately after surgery, serum chloride levels were significantly higher in the NS group. Compared to the NS group, the BC group had lower incidence rates of acidemia (6.5% vs. 11.6%, p=0.043) and metabolic acidosis (0.7% vs. 4.4%, p=0.007). As compared to NS group, BC group had significantly shorter duration from the end of the operation to extubation (250±824 vs. 122±372 minutes, p=0.016) and length of stay in ICU (1.37±1.11 vs. 1.12±0.61 days, p=0.001). Throughout multivariable analysis, use of BC was found to be significant factor for favorable post-operative results.
Conclusion
: This study showed that the patients who received BC during UIA clipping had lower incidence of metabolic acidosis, earlier extubation and shorter ICU stay compared to those who received NS. Therefore, using BC as a peri-operative fluid can be recommended for patients who undergo surgery for UIA.

Keyword

Balanced crystalloid; Normal saline; Intracranial aneurysm, Unruptured; Crystalloid solutions; Acidosis; Fluid therapy

Figure

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  Fig. 1. Flowchart shows enrollment of study subjects. Following the inclusion and exclusion criteria, a total 906 patients (293 NS group and 613 BC group) were matched by propensity score. As a result, 293 patients are allocated to each group. UIA : unruptured intracranial aneurysm, NS : normal saline, BC : balanced crystalloid, ICU : intensive care unit.

Reference

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