Korean J Urol Oncol.
2021 May;19(2):101-108. 10.22465/kjuo.2021.19.2.101.
Utility of Next-Generation Sequencing for Deciphering Intratumor Heterogeneity in Prostate Cancer
- Affiliations
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- 1Samsung Genome Institute, Samsung Medical Center, Seoul, Korea
- 2Center for Health Promotion, Samsung Medical Center, Seoul, Korea
- KMID: 2516482
- DOI: http://doi.org/10.22465/kjuo.2021.19.2.101
Abstract
- Prostate cancer has long been considered a disease with a heterogeneous phenotype. The intratumor heterogeneity (ITH) may affect diverse phenotypes such as treatment response, drug resistance, and overall clinical outcomes. Despite technical advances over the past decade, we have an incomplete understanding of the extent and effects of ITH in prostate cancer progression. We present here a comprehensive review of the various studies dealing with ITH in prostate cancer. We discuss the advanced next-generation sequencing analyses including single cell sequencing and circulating cell-free DNA sequencing that have the impact of heterogeneity on clinical decision making.
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