J Vet Sci.  2021 May;22(3):e34. 10.4142/jvs.2021.22.e34.

Anti-lipopolysaccharide antibody mitigates ruminal lipopolysaccharide release without acute-phase inflammation or liver transcriptomic responses in Holstein bulls

• Mizuguchi H
• Kizaki K
• Kimura A
• Kushibiki S
• Ikuta K
• Kim YH
• Sato S

• KMID: 2516207
• DOI: http://doi.org/10.4142/jvs.2021.22.e34

Abstract

Anti-lipopolysaccharide (LPS) antibody administration has the potential benefits of neutralizing and consequently controlling rumen-derived LPS during subacute ruminal acidosis. Four Holstein bulls were used in this crossover study with a 2-week wash-out period. Anti-LPS antibody (0 or 4 g) was administered once daily for 14 days. Significantly lower ruminal LPS and higher 1-h mean ruminal pH were identified in the 4 g group. However, blood metabolites, acute-phase proteins, cytokines, and hepatic transcriptomes were not different between the two groups. Therefore, anti-LPS antibody administration mitigated ruminal LPS release and pH depression without accompanying responses in acute-phase inflammation or hepatic transcriptomic expression.

Keyword

Anti-lipopolysaccharide antibody; cattle; liver transcriptome; rumen fermentation; subacute ruminal acidosis