J Korean Ophthalmol Soc.  2021 May;62(5):605-611. 10.3341/jkos.2021.62.5.605.

Clinical Outcomes between Amniotic Membrane Transplantation and Conjunctival Autograft Using Fibrin Glue for Pterygium Surgery

• Lee SJ
• Yang HS
• Choi JH
• Yu J
• Chung YR

• KMID: 2515942
• DOI: http://doi.org/10.3341/jkos.2021.62.5.605

Abstract

Purpose
We compared clinical outcomes including recurrence rate between amniotic membrane transplantation (AMT) and conjunctival autograft using fibrin glue and minimal conjunctival sutures for pterygium surgery.
Methods
We retrospectively analyzed 217 eyes of 198 patients with pterygia who underwent surgery from May 2016 to December 2019. Pterygium excision was performed with conjunctival autograft or AMT, using fibrin glue with both. Recurrence rates and complications were evaluated between the two groups.
Results
Postoperative recurrences were noted in one of 185 eyes (0.5%) in the conjunctival autograft group, and in six of 32 eyes (18.8%) in the AMT group. The recurrence rate was significantly lower in the conjunctival autograft group (p < 0.001). Logistic regression analysis revealed that conjunctival autograft was associated with a significantly lower risk of pterygium recurrence compared to AMT (odds ratio, 0.023; 95% confidence interval, 0.003-0.206; p = 0.001). No ocular complication was noted in both groups during follow-up.
Conclusions
Pterygium excision with conjunctival autograft using fibrin glue was more effective in preventing recurrence compared to AMT.

Keyword

Amniotic membrane, Autograft, Fibrin glue, Pterygium, Recurrence