J Korean Neurol Assoc.  2021 May;39(2):85-88. 10.17340/jkna.2021.2.5.

Pathologically and Genetically Diagnosed Subclinical Symptomatic Duchenne Muscular Dystrophy Carrier: Broadened Spectrum of Clinical Phenotype

Affiliations
  • 1Department of Neurology, Kyungpook National University Hospital, Daegu, Korea
  • 2Department of Neurology, School of Medicine, Kyungpook National University, Daegu, Korea

Abstract

A 29-year-old female presented with an elevated level of serum creatine kinase without subjective weakness. Neurologic examination showed the subtle motor weakness of the right arm. Muscle biopsy showed dystrophic changes and a mosaic pattern of dystrophin expression. The diagnosis was confirmed by multiplex ligation-dependent probe amplification and whole-exome sequencing, revealing heterozygous deletion of exon 44 in the DMD gene. Here, we introduce a subclinical symptomatic Duchenne muscular dystrophy carrier, which broadens the clinical spectrum of phenotype.

Keyword

Muscular dystrophy; duchenne; Multiplex polymerase chain reaction; Immunohistochemistry; Dystrophin
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