J Korean Neurol Assoc.
2021 May;39(2):82-84. 10.17340/jkna.2021.2.4.
Subacute Combined Degeneration with Motor Neuropathy Following Nitrous Oxide Abuse
- Affiliations
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- 1Department of Neurology, School of Medicine, Catholic University of Daegu, Daegu, Korea
- KMID: 2515615
- DOI: http://doi.org/10.17340/jkna.2021.2.4
Abstract
- The neurotoxicity of nitrous oxide (N2O) is known to be mainly occurred by interference with action of vitamin B12. A 38-year-old male presented with progressive gait instability after recreational inhalational use of N2O for 2 months. Although spine magnetic resonance image showed typical subacute combined degeneration, nerve conduction study showed motor neuropathy that is atypical findings of vitamin B12 deficiency. This case suggests N2O-induced neuropathy can develop separately from a vitamin B12 deficiency.
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