Clin Exp Otorhinolaryngol.  2021 May;14(2):240-243. 10.21053/ceo.2020.00885.

Laryngopharyngeal Reflux Alters Macrophage Polarization in Human Papilloma Virus-Negative Squamous Cell Carcinoma of the Larynx in Males

Affiliations
  • 1Kolomiychenko Institute of Otolaryngology of National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
  • 2Department of Histopathology, Laboratory of Pathology CSD, Kyiv, Ukraine


Figure

  • Fig. 1. Differences in inflammatory infiltration in patients with laryngeal squamous cell carcinoma (LSCC) with regard to laryngopharyngeal reflux (LPR). Group 1 included patients with LSCC without LPR, and group 2 comprised patients with LSCC+LPR. (A-D) Staining with H&E. (E-H) Immunohistochemistry using antibodies against CD68 (E, F) and CD163 (G, H). Magnification, ×200.

  • Fig. 2. Number of macrophage subtypes in different compartments of laryngeal squamous cell carcinoma (LSCC) according to the coexistence of laryngopharyngeal reflux (LPR). LSCC with coexisting LPR demonstrated a higher number of M2-type macrophages and a higher CD163/CD68 ratio in all compartments of the tumor. *P<0.05.


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