Brain Tumor Res Treat.  2021 Apr;9(1):31-34. 10.14791/btrt.2021.9.e6.

Cerebellar Glioependymal Cyst

Affiliations
  • 1Department of Neurosurgery, Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea

Abstract

Glioependymal cyst (GEC) is an uncommonly observed clinical entity in the posterior cranial fossa. A 36-year-old female with cystic lesion in the right cerebellum was hospitalized for evaluating headache and dizziness. Brain images showed a well-defined, ovoid mass adjacent to the fourth ventricle. After drainage and excision of the cyst, the patient became symptom free. Pathology examination disclosed low cuboidal epithelium and glial cells in the cyst wall. The radiological features, neurological manifestations, and the operations for GECs of the present localization are described in this short communication.

Keyword

Glioependymal cyst; Neuroepithelial cyst; Cerebellum

Figure

  • Fig. 1 Radiology of glioependymal cyst in the cerebellum. A and B: The signal intensities of lesion are identical to cerebrospinal fluid in both T2-weighted and fluid attenuated inversion recovery MRI images. C: No abnormal enhancement is observed after gadolinium administration. D: Dynamic CT taken 15 years after the surgery depicts disappearance of the lesion.

  • Fig. 2 Microphotography exhibits stratified flattened cuboidal epitheliums and underlying neuroglial tissue in the cyst wall (H&E, ×200).


Reference

1. Robles LA, Paez JM, Ayala D, Boleaga-Duran B. Intracranial glioependymal (neuroglial) cysts: a systematic review. Acta Neurochir (Wien). 2018; 160:1439–1449. PMID: 29802560.
2. Schelper RL, Ramzy I, Durr N. Ependymal cyst of the subarachnoid space. Cytologic diagnosis and developmental considerations. Acta Cytol. 1985; 29:44–48. PMID: 3855586.
3. Cavalheiro S, Canullo ML, Silva da Costa MD, Dastoli PA, Mendonça Nicácio J, Stavale JN. Glioependymal cyst on the third cranial nerve: case report. J Neurosurg Pediatr. 2020; 25:178–182.
4. Saito K, Morita A, Shibahara J, Kirino T. Spinal intramedullary ependymal cyst: a case report and review of the literature. Acta Neurochir (Wien). 2005; 147:443–446. discussion 446. PMID: 15666187.
5. Qi X, Xie D, Wan Y, et al. Glioependymal cyst of frontal lobe. Neurosurg Q. 2015; 25:280–282.
6. Monaco P, Filippi S, Tognetti F, Calbucci F. Glioependymal cyst of the cerebellopontine angle. J Neurol Neurosurg Psychiatry. 1995; 58:109–110.
7. Elmadbouh H, Halpin SF, Neal J, Hatfield RH, Hourihan MD. Posterior fossa epithelial cyst: case report and review of the literature. AJNR Am J Neuroradiol. 1999; 20:681–685. PMID: 10319981.
8. Ho KL, Chason JL. A glioependymal cyst of the cerebellopontine angle. Immunohistochemical and ultrastructural studies. Acta Neuropathol. 1987; 74:382–388. PMID: 3500568.
9. Tsuchida T, Kawamoto K, Sakai N, Tsutsumi A. Glioependymal cyst in the posterior fossa. Clin Neuropathol. 1997; 16:13–16. PMID: 9020388.
10. Harada A, Takeuchi S, Inenaga C, et al. Hemifacial spasm associated with an ependymal cyst in the cerebellopontine angle. J Neurosurg. 2002; 97:482–485. PMID: 12186482.
11. Shenouda EF, Moss TH, Coakham HB. Cryptic cerebellopontine angle neuroglial cyst presenting with hemifacial spasm. Acta Neurochir (Wien). 2005; 147:787–789. discussion 789. PMID: 15900403.
12. Endo H, Fujimura M, Watanabe M, Tominaga T. Neuro-endoscopic management of mesencephalic intraparenchymal cyst: a case report. Surg Neurol. 2009; 71:107–110. discussion 110. PMID: 18291476.
13. Park BJ, Kim YI, Jeun SS, Lee YS. An ependymal cyst in cerebello-pontine angle presenting with syncope. Brain Tumor Res Treat. 2013; 1:121–123. PMID: 24904905.
14. Prieto R, Subhi-Issa I, Pascual JM. Ependymal cyst of the midbrain. Clin Neuropathol. 2013; 32:183–188. PMID: 23254139.
15. Andrews BT, Halks-Miller M, Berger MS, Rosenblum ML, Wilson CB. Neuroepithelial cysts of the posterior fossa: pathogenesis and report of two cases. Neurosurgery. 1984; 15:91–95. PMID: 6332281.
16. Cho HJ, Kim HN, Kim KJ, et al. Intracranial extracerebral glioneuronal heterotopia with adipose tissue and a glioependymal cyst: a case report and review of the literature. Korean J Pathol. 2014; 48:254–257. PMID: 25013427.
17. Vasquez CA, Casey M, Folzenlogen Z, Ormond DR, Lillehei K, Youssef AS. Third ventricular cerebrospinal fluid cysts of thalamic origin: review of embryologic origin, presentation, and management strategies with a case series. World Neurosurg. 2017; 103:210–219. PMID: 28391023.
18. Alvarado AM, Smith KA, Chamoun RB. Neuroendoscopic fenestration of glioependymal cysts to the ventricle: report of 3 cases. J Neurosurg. 2019; 131:1615–1619.
19. Goh RH, Maguire J. Neuroepithelial cyst of the posterior fossa: two case reports with radiologic-pathologic correlation. Can Assoc Radiol J. 1996; 47:126–131. PMID: 8612085.
20. Umredkar A, Mohindra S, Gupta R, Bal AK. Contrasting behavior of glio-ependymal cysts: a report of two cases and literature review. Neurol India. 2010; 58:659–661. PMID: 20739818.
21. Heran NS, Berk C, Constantoyannis C, Honey CR. Neuroepithelial cysts presenting with movement disorders: two cases. Can J Neurol Sci. 2003; 30:393–396. PMID: 14672275.
22. Ferreira T, Khurana D, Mohindra S, Gupta K. Hemiatrophy as a presentation of a glioependymal cyst. Clin Neurol Neurosurg. 2014; 124:6–7. PMID: 24976022.
23. El Damaty A, Marx S, Fleck S, Schroeder HW. Neuroendoscopic approach to intracranial ependymal cysts. World Neurosurg. 2017; 97:383–389. PMID: 27751924.
24. Hasegawa H, Ushio Y, Oku Y, Iwata Y, Kanai N, Kamikawa K. Neuroepithelial cyst of the cerebellar vermis. Surg Neurol. 1976; (3):181–184. PMID: 959991.
25. Markwalder TM, Markwalder RV, Slongo T. Intracranial ciliated neuroepithelial cyst mimicking arachnoid cyst. Surg Neurol. 1981; 16:411–414. PMID: 7330761.
26. Osborn AG, Preece MT. Intracranial cysts: radiologic-pathologic correlation and imaging approach. Radiology. 2006; 239:650–664. PMID: 16714456.
27. Boockvar JA, Shafa R, Forman MS, O'Rourke DM. Symptomatic lateral ventricular ependymal cysts: criteria for distinguishing these rare cysts from other symptomatic cysts of the ventricles: case report. Neurosurgery. 2000; 46:1229–1232. PMID: 10807256.
28. Conrad J, Welschehold S, Charalampaki P, van Lindert E, Grunert P, Perneczky A. Mesencephalic ependymal cysts: treatment under pure endoscopic or endoscope-assisted keyhole conditions. J Neurosurg. 2008; 109:723–728. PMID: 18826361.
29. Lee SJ, Hong CK, Ahn JY, Lee KS. Progressively enlarged intracerebral ependymal cyst presenting with movement disorder. J Korean Neurosurg Soc. 2007; 41:252–254.
Full Text Links
  • BTRT
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr