Nucl Med Mol Imaging.  2021 Apr;55(2):86-95. 10.1007/s13139-020-00680-5.

Development of GATE Monte Carlo Code for Simulation and Dosimetry of New I-125 Seeds in Eye Plaque Brachytherapy

• Taherparvar P
• Fardi Z

• KMID: 2515027
• DOI: http://doi.org/10.1007/s13139-020-00680-5

Abstract

Purpose
Dose distributions are calculated by Monte Carlo (MC) simulations for two low-energy models ¹²⁵ I brachytherapy source—IrSeed-125 and IsoAid Advantage (model IAI-125A)—loaded in the 14-mm standardized plaque of the COMS during treatment of choroid melanoma.
Methods
In this study, at first, the radial dose function in water around ¹²⁵ I brachytherapy sources was calculated based on the recommendations of the Task Group No. 43 American Association of Physicists in Medicine (TG-43U1 APPM) using by GATE code. Then, brachytherapy dose distribution of a new model of the human eye was investigated for a 14-mm COMS eye plaque loaded with these sources with GATE Monte Carlo simulation.
Results
Results show that there are good agreements between simulation results of these sources and reporting measurements and simulations. Dosimetry results in the designed eye phantom for two types of iodine seeds show that the ratios of average dose of tumor to sclera, vitreous, and retina for IrSeed (IsoAid) source are 3.7 (3.7), 6.2 (6.1), and 6.3 (6.3), respectively, which represents the dose saving to healthy tissues. The maximum percentage differences between DVH curve of IsoAid and IrSeed seeds was about 8%.
Conclusions
Our simulation results show that although new model of the ¹²⁵ I brachytherapy source having a slightly larger dimension than IAI-125A, it can be used for eye melanoma treatment because the COMS eye plaque loaded with IrSeed-125 could produce similar results to the IsoAid seeds, which is applicable for clinical plaque brachytherapy for uveal melanoma.

Keyword

Ocular melanoma; Brachytherapy; Low-energy sources; GATE Monte Carlo