Cancer Res Treat.  2021 Apr;53(2):355-366. 10.4143/crt.2020.847.

A Nationwide, Population-Based Epidemiology Study of Primary Central Nervous System Tumors in Korea, 2007-2016: A Comparison with United States Data

• Kang H
• Song SW
• Ha J
• Won YJ
• Park CK
• Yoo H
• Jung KW

• KMID: 2514918
• DOI: http://doi.org/10.4143/crt.2020.847

Abstract

Purpose
The purpose of this study was to determine the epidemiologic characteristics and survival of patients with primary brain and other central nervous system (CNS) tumors in Korea and to compare our findings with those from the United States.
Materials and Methods
We collected data on primary brain and CNS tumors diagnosed between 2007 and 2016 from the Korea Central Cancer Registry. The age-standardized incidence rates (ASRs) and 5-year relative survival rates (RSRs) were evaluated. We applied the classification and definitions of the Central Brain Tumor Registry of the United States to our analysis for direct comparison with United States data.
Results
A total of 115,050 primary brain and CNS tumors were identified, and the ASR of all tumors was 22.01 per 100,000 individuals, which was lower than the 23.41 in the United States. However, the ASR of malignant tumors was significantly lower herein (4.27) than in the United States (7.08). Meningeal tumors were the most common histologic group among all tumors (ASR, 8.32). The 5-year RSR of all primary brain and other CNS tumors was 86.4%, and that of all malignant tumors was 44.1%, which was higher than the 35.8% observed in the United States. Among malignant tumors, glioblastomas had the lowest 5-year RSR (12.1%).
Conclusion
In Korea, malignant brain and other CNS tumors have a lower incidence and better survival outcome.

Keyword

Epidemiology; Brain neoplasms; Incidence; Survival rate

Figure

• 

  Fig. 1 Comparison of incidence of primary brain and central nervous system tumors by age groups between Korea and the United States. Our data was from the KCCR, 2007–2016; U.S. data was from CBTRUS, 2012–2016. We standardized to U.S. 2000 population to directly compare our incidences to those of the United States. CB­TRUS, Central Brain Tumor Registry of the United States; KCCR, Korean Central Cancer Registry.

• 

  Fig. 2 Distribution of primary brain and other CNS tumors by location, sex and malignancy. (A) The distribution of all types of primary brain and other CNS tumors by location and behavior. (B) The distribution of all types of primary brain and other CNS tumors by location and sex. (C) Comparison of M:F rate ratio by histology between the United States and Korea. CBTRUS, Central Brain Tumor Registry of the United States; CNS, central nervous system; KCCR, Korean Central Cancer Registry; M:F rate ratio, male-to-female incidence rate ratio. *A statistically significant difference between sexes.

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  Fig. 3 Incidence trend of primary brain and other central nervous system tumors by behavior and age group. *A statistically significant annual percent changes (APC).

Reference

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