Ann Surg Treat Res.  2021 Apr;100(4):235-245. 10.4174/astr.2021.100.4.235.

Postoperative outcomes of purely laparoscopic donor hepatectomy compared to open living donor hepatectomy: a preliminary observational study

Affiliations
  • 1Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
  • 2Department of Anesthesiology and Pain Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea
  • 3Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

Abstract

Purpose
To lessen the physical, cosmetic, and psychological burden of donors, purely laparoscopic donor hepatectomy (PLDH) has been proposed as an ideal method for living donors. Our study aimed to prospectively compare the effect of PLDH and 2 other types of open living donor hepatectomy (OLDH) on postoperative pain and recovery.
Methods
Sixty donors scheduled to undergo donor hepatectomy between March 2015 and November 2017 were included. Donors were divided into 3 groups by surgical technique: OLDH with a subcostal incision (n = 20), group S; OLDH with an upper midline incision (n = 20), group M; and PLDH (n = 20), group L. The primary outcomes were postoperative pain and analgesic requirement during postoperative day (POD) 3. Other variables regarding postoperative recovery were also analyzed.
Results
Although pain relief during POD 3, assessed by visual analog scale (VAS) score and analgesic requirement, was similar among the 3 groups, group L showed lower VAS scores and opioid requirements than group M. Moreover, group L was associated with a rapid postoperative recovery evidenced by the shorter hospital length of stay and more frequent return to normal activity on POD 30.
Conclusion
This pilot study failed to verify the hypothesis that PLDH reduces postoperative pain. PLDH did not reduce postoperative pain but showed faster recovery than OLDH.

Keyword

Laparoscopy; Liver transplantation; Living donors; Postoperative pain; Treatment outcome

Figure

  • Fig. 1 Three surgical techniques for living donor hepatectomy. (A) Group S (open living donor hepatectomy with a subcostal incision). (B) Group M (open living donor hepatectomy with an upper midline incision). (C) Group L (purely laparoscopic living donor hepatectomy).

  • Fig. 2 Visual analog scale of pain (VAS, 0–100 mm) at rest and when coughing. (A) VAS at rest. (B) VAS when coughing. The bar plots with error bars indicate mean values and standard errors. *P < 0.05.

  • Fig. 3 Opioid consumption during the first 72 hours postoperative. (A) Intravenous patient-controlled analgesia (IV PCA) consumption (morphine equivalent dose). (B) Cumulative opioid consumption (morphine equivalent dose). (C) Number of rescue opioid administrations. The bar plots with error bars indicate mean values and standard errors. *P < 0.05.

  • Fig. 4 Serial changes in the perioperative ALT, AST, total bilirubin, and PT (INR) levels. The bar plots with error bars indicate mean values and standard errors. Preop, preoperative. *P < 0.05.


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