Korean J Dermatol.  2021 Mar;59(3):188-195.

Chondroid Syringoma: A Clinical and Histopathological Study of 17 Cases

Affiliations
  • 1Department of Dermatology, Inha University School of Medicine, Incheon, Korea

Abstract

Background
Chondroid syringoma (CS) is an uncommon benign neoplasm of the head and neck seen in middle-aged to elderly individuals. Histopathologically, chondroid syringoma displays nests of cuboidal epithelial cells embedded in a matrix. It is classified as both a tubular branching lumina type and a small tubular lumina type and may exhibit a wide range of differentiation and metaplastic changes in the epithelial and stromal components.
Objective
To investigate the correlation between the clinical and histopathologic features of chondroid syringoma.
Methods
We evaluated the electronic medical records, clinical photographs, and histopathological slides of 17 patients diagnosed with chondroid syringoma.
Results
CS in the terminal hair skin tended to have larger lesions (p=0.036). Tumors in terminal hair skin demonstrated significantly more follicular differentiation (p=0.044) than those in the vellus hair skin. CS arising on the scalp tended to have more osseous metaplasia compared to those arising on non-scalp areas (p=0.022).
Conclusion
This study showed that the clinical and histopathological features of CS can differ depending on its location.

Keyword

Chondroid syringoma; Clinical; Histopathologic
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