Psychiatry Investig.  2021 Mar;18(3):205-213. 10.30773/pi.2020.0101.

The Interaction of Inflammatory Markers and Alcohol-Use on Cognitive Function in Korean Male Firefighters

Affiliations
  • 1Department of Neuropsychiatry, Eulji University School of Medicine, Daejeon, Republic of Korea
  • 2Department of Neuropsychiatry, Eulji University Hospital, Daejeon, Republic of Korea
  • 3Department of Preventive Medicine, Institute Occupational and Environmental Medicine, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea
  • 4Yonsei University Wonju College of Medicine, Wonju, Republic of Korea

Abstract


Objective
Cognitive functions have been shown to become impaired due to alcoholism. Recently, neuroinflammation gained attention for playing a role in the neurotoxic effect of alcohol. However, there is limited data on the relationship between alcohol and cognitive function, based on the mechanism of inflammation. This study examined whether the interaction between alcohol use and pro-inflammatory biomarkers is related to cognitive function in Korean male firefighters.
Methods
A total of 474 firefighters were assessed for alcohol-related problems using CAGE, cognitive functions, and pro-inflammatory biomarkers (CRP, IL-6, TNF-α). Sequential multiple regression analyses were conducted to determine if inflammatory markers moderate the relationship between alcohol use and cognitive function.
Results
Only a decreased attentional function was associated with the interaction of alcohol use and inflammatory markers, after controlling for age, sex, body mass index, lipid profiles, smoking, depression, fatigue, self-reported hypertension, diabetes, and musculoskeletal problems.
Conclusion
This study revealed that the interaction between alcohol use and inflammation is related to attentional function in Korean male firefighters. Additionally, this cross-sectional study suggests that diminishing attention, related to alcohol use, may be based on the mechanism of inflammation.

Keyword

Alcohol dependence, Attention, Cognitive decline, Firefighter, Inflammatory marker
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