J Bone Metab.  2021 Feb;28(1):11-26. 10.11005/jbm.2021.28.1.11.

Effect of Vitamin K₂ Alone or in Combination on Various Bone Turnover Markers Amongst Postmenopausal Females

• AlHajri L
• Ayoub A
• Ahmed H
• AlMulla M

• KMID: 2513875
• DOI: http://doi.org/10.11005/jbm.2021.28.1.11

Abstract

Background
Osteoporosis is common in postmenopausal women. Some studies have demonstrated the usefulness of vitamin K through the action of bone-specific proteins and osteoblast and osteoclast activities. However, no systematic review had explored this aspect in postmenopausal women. Hence, this systematic review aimed to explore the effect of vitamin K₂ alone or in combination with other agents (vitamin D₃ or calcium) on various bone turnover markers (BTMs) and bone mineral density (BMD) in postmenopausal women.
Methods
MEDLINE, ScienceDirect, PubMed, and Google Scholar were searched to identify relevant studies using specific inclusion criteria. Data extraction and quality assessment were carried out using standardized tests, and the results were narratively synthesized and presented in the form of tables.
Results
Vitamin K₂ was beneficial in inducing an improvement or preventing deterioration, as evidenced by the BMD and osteocalcin (OC), undercarboxylated OC (ucOC), carboxylated OC (cOC), and γ-carboxylated OC levels. However, its effect was not conclusive when procollagen type 1 N-terminal propeptide, carboxyterminal propeptide of type I procollagen, C-terminal telopeptide of type I collagen, bone alkaline phosphatase, deoxypyridinoline, and N-terminal telopeptide levels (NTX) and ucOC:cOC or cOC:ucOC, and NTX:creatinine ratios were examined.
Conclusions
Vitamin K₂ supplementation combined with vitamin D and calcium was found to be advantageous. However, vitamin K₂ supplementation cannot replace the existing treatment options. In addition, vitamin K₂ should be used with caution, considering its interactions with food and other drugs.

Keyword

Biomarkers · Osteoporosis, postmenopausal · Vitamin K₂