Neonatal Med.  2021 Feb;28(1):7-13. 10.5385/nm.2021.28.1.7.

Effects of Oxygen Saturation Fluctuations on Retinopathy in Infants Younger than 30 Weeks’ Gestational Age

• Jeon CW
• Kim JS
• Park B
• Lee JH

• KMID: 2513353
• DOI: http://doi.org/10.5385/nm.2021.28.1.7

Abstract

Purpose
To evaluate the risk factors and effects of fluctuations in oxygen saturation on the occurrence and severity of retinopathy of prematurity (ROP).
Methods
From January 1, 2013 to January 31, 2020, 260 patients hospitalized in the neonatal intensive care unit of Ajou University Hospital were retrospectively analyzed.
Results
Sixty-six patients (25%) were diagnosed with ROP; of them 39 required treatment. In the multivariate regression analysis of ROP severity, the odds ratio (OR) of gestational age was 0.32 (95% confidence interval [CI], 0.22 to 0.47; P<0.0001). The OR of saturation of peripheral oxygen (SpO₂) fluctuations at the 4th week after birth was 1.02 (95% CI, 1.02 to 1.12; P=0.041).
Conclusion
SpO₂ fluctuations in premature infants younger than 30 weeks’ gestational age affects ROP severity, especially at the 4th week of life.

Keyword

Retinopathy of prematurity; Risk factors; Oxygen

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