Osong Public Health Res Perspect.  2021 Feb;12(1):3-12. 10.24171/j.phrp.2021.12.1.02.

A Healthcare-Associated Outbreak of HCV Genotype 2a at a Clinic in Seoul

Affiliations
  • 1Jeju Branch Office, Honam Regional Center for Disease and Prevention, Korea Disease Control and Prevention Agecy, Jeju, Korea
  • 2Division of Immunization, Bureau of Healthcare Safety and Immunization, Korea Disease Control and Prevention Agecy, Cheongju, Korea
  • 3Korea Disease Control and Prevention Agecy, Cheongju, Korea
  • 4Division of Infectious Disease Diagnosis Control, Honam Regional Center for Disease and Prevention, Korea Disease Control and Prevention Agecy, Gwangju, Korea

Abstract


Objectives
An epidemiological investigation was conducted into a hepatitis C virus (HCV) outbreak at an outpatients clinic in Seoul (2011-2012). The aim of the study was to analyze the scale of infection, identify the source of infection, and route of transmission to prevent hepatitis C transmission in the future.
Methods
A retrospective study of the outpatients and health care workers (n = 7,285) in the target outpatient clinic during 2011-2012 was conducted. The history of the study population infection with hepatitis C, electronic medical records, field visits, and health care worker interviews were examined for the period between March 1>st , 2006 and March 25th , 2016. The blood samples were collected and tested for anti-HCV antibodies, HCV RNA and HCV gene in 2016.
Results
The rate of anti-HCV positive results was 4.4% in the study population. The risk factors associated with an anti-HCV positive result were ≥ 10 clinic visits, and receiving an invasive procedure including a nerve block and a block of the peripheral branch of the spinal nerve (p < 0.05). There were 112 HCV RNA positive cases out of 320 anti-HCV positive test result cases, amongst which 100 cases had the dominant HCV genotype 2a which formed either 1 cluster (n = 56) or 2 clusters (n = 25). This result indicated exposure to a high-association infection source.
Conclusion
Anti-HCV antibodies and genotypic analysis showed an epidemiological association between the outbreak of HCV and invasive procedures performed (2011-2012) at an outpatients clinic in Seoul.

Keyword

epidemiology; hepatitis C virus; invasive; procedures
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