Investig Clin Urol.  2021 Mar;62(2):148-158. 10.4111/icu.20200392.

A state-of-art review on the preservation of sexual function among various minimally invasive surgical treatments for benign prostatic hyperplasia: Impact on erectile and ejaculatory domains

  • 1Department of Urology, Princess Alexandra Hospital, University of Queensland, Brisbane, QLD, Australia
  • 2AndroUroloogy Centre, Brisbane, QLD, Australia
  • 3Department of Urology, Macquarie University Hospital, Sydney, NSW, Australia


There is a strong association between benign prostatic hyperplasia (BPH)/lower urinary tract symptoms (LUTS) and sexual dysfunction. While transurethral resection of the prostate (TURP) is considered the standard BPH treatment, it is however associated with a high rate of erectile and ejaculatory dysfunctions. Over the past decade, new and novel minimally invasive BPH therapies have been shown to improve various parameters of voiding domains while minimizing adverse sexual effects. These minimally invasive BPH therapies can be largely be divided into those with cavitating technology (Rezum, Histotripsy, Aquablation), intra-prostatic injections (Botulinum neurotoxin Type A, Fexapotide Triflutate, prostate specific antigen-activated protoxin PRX-302), and mechanical devices which include intraprostatic stents (Urospinal 2TM , MemothermTM , MemokathTM , and Allium triangular prostatic stentTM ) and intraprostatic devices (iTINDTM , UroliftTM ), as well as prostatic artery embolization. Published literature on these technologies showed reasonable preservation of erectile function with limited data reported on ejaculatory domain. Further validation of the performance of these novel minimally invasive treatment options for LUTS due to BPH in well-designed and multi-centre studies are desired, to evaluate their role (or lack of such a role) in clinical practice and whether these BPH therapies can provide equivalent standard or better than TURP.


Benign prostatic hyperplasia; Clinical outcomes; Sexual dysfunction; Surgery
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