Ann Lab Med.  2021 Mar;41(2):243-246. 10.3343/alm.2021.41.2.243.

A Case of IgG4-related Disease With Bone Marrow Involvement: Bone Marrow Findings and Flow Cytometric Immunophenotyping of Plasma Cells

• Kim HJ
• You E
• Hong S
• Park CJ

• KMID: 2512673
• DOI: http://doi.org/10.3343/alm.2021.41.2.243

Figure

• 

  Fig. 1 Morphologic and IHC findings of PB and BM samples, and flow cytometric immunophenotyping of PC. (A) Eosinophilia, poikilocytosis (schistocytes and spherocytes), and rouleaux formation (PB, Wright stain, × 400). (B) Increased numbers of PC including immature forms with slightly high NC ratio, nucleolus, and perinuclear halo (BM aspirate, Wright stain, × 1,000). (C) Increased number of eosinophils (BM aspirate, Wright stain, × 1,000). (D) Increased number of eosinophils and PC (BM biopsy, H & E stain, × 400). (E) Increased number of PC (BM clot section, IHC stain for CD138, × 1,000). (F) Increased numbers of IgG4+ PC (BM biopsy, IHC stain for IgG4, × 1,000). (G, H) Presence of atypical PC with the immunophenotypes CD38+/CD138dim/CD56−/CD19low/CD45+ in PB and CD38+/CD138+/CD56+/CD19low/CD45low in BM aspirates. Abbreviations: IHC, immunohistochemistry; PB, peripheral blood; BM, bone marrow; PC, plasma cells.

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