Korean J Dermatol.  2021 Jan;59(1):33-37.

Clinical Features of Verruca Plana and Verruca Plana-Like Seborrheic Keratosis

• Lee JY
• Lee AY
• Lee SH
• Hong JS

Abstract

Background
Differentiating between verruca plana (VP) and VP-like seborrheic keratosis (SK) is difficult and little research has been performed on the topic.
Objective
The aim of this study was to elucidate clinical differences between these two diseases.
Methods
We conducted a retrospective review of cases of VP and VP-like SK identified by biopsy. Demographics (age and gender) and clinical information (location, color, distribution, and shape) were collected.
Results
A total of 224 cases were identified. Thirty-nine cases were finally diagnosed with VP (17.4%) and 159 cases with VP-like SK (71.0%). The rest of the diagnoses accounted for 26 cases. On multivariate analysis, extremities (odds ratio [OR] 7.91, confidence interval [CI] 2.61∼23.93), flesh color (OR 3.69, CI 1.43∼9.49), erythematous color (OR 36.83, CI 7.50∼180.84), and clustered distribution (OR 4.73, CI 1.66∼13.46) were significantly associated with VP. Shape is not predictive in VP occurence.
Conclusion
We provide clinical information regarding the differentiation of VP and VP-like SK, which should prove useful in clinical dermatological practice.

Keyword

Differential diagnosis; Seborrheic keratosis; Verruca