J Stroke.  2021 Jan;23(1):135-138. 10.5853/jos.2020.04658.

Golden Hour Thrombolysis in Acute Ischemic Stroke: The Changing Pattern in South Korea

• Kim H
• Kim JT
• Lee JS
• Kim BJ
• Park JM
• Kang K
• Lee SJ
• Kim JG
• Cha JK
• Kim DH
• Park TH
• Park SS
• Lee KB
• Lee J
• Hong KS
• Cho YJ
• Park HK
• Lee BC
• Yu KH
• Oh MS
• Kim DE
• Ryu WS
• Choi JC
• Kwon JH
• Kim WJ
• Shin DI
• Sohn SI
• Hong JH
• Park MS
• Choi KH
• Cho KH
• Lee J
• Bae HJ

• KMID: 2512364
• DOI: http://doi.org/10.5853/jos.2020.04658

Figure

• 

  Figure 1. Annual changes in intravenous tissue plasminogen activator treatment times. (A) Onset-to-treatment (OTT) time and the proportions of OTT times ≤60 minutes; (B) door-to-treatment (DTT) time and the proportions of DTT times ≤30 minutes; and (C) onset-to-door (OTD) time and the proportions of OTD times ≤30 minutes.

Reference

References

1. Kim JT, Fonarow GC, Smith EE, Reeves MJ, Navalkele DD, Grotta JC, et al. Treatment with tissue plasminogen activator in the golden hour and the shape of the 4.5-hour time-benefit curve in the national United States get with the guidelines-stroke population. Circulation. 2017; 135:128–139.

2. Emberson J, Lees KR, Lyden P, Blackwell L, Albers G, Bluhmki E, et al. Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials. Lancet. 2014; 384:1929–1935.

3. Tsivgoulis G, Katsanos AH, Kadlecová P, Czlonkowska A, Kobayashi A, Brozman M, et al. Intravenous thrombolysis for ischemic stroke in the golden hour: propensity-matched analysis from the SITS-EAST registry. J Neurol. 2017; 264:912–920.

4. Fonarow GC, Zhao X, Smith EE, Saver JL, Reeves MJ, Bhatt DL, et al. Door-to-needle times for tissue plasminogen activator administration and clinical outcomes in acute ischemic stroke before and after a quality improvement initiative. JAMA. 2014; 311:1632–1640.

5. Kamal N, Holodinsky JK, Stephenson C, Kashayp D, Demchuk AM, Hill MD, et al. Improving door-to-needle times for acute ischemic stroke: effect of rapid patient registration, moving directly to computed tomography, and giving alteplase at the computed tomography scanner. Circ Cardiovasc Qual Outcomes. 2017; 10:e003242.

6. Kassardjian CD, Willems JD, Skrabka K, Nisenbaum R, Barnaby J, Kostyrko P, et al. In-patient code stroke: a quality improvement strategy to overcome knowledge-to-action gaps in response time. Stroke. 2017; 48:2176–2183.

7. Heo JH, Kim YD, Nam HS, Hong KS, Ahn SH, Cho HJ, et al. A computerized in-hospital alert system for thrombolysis in acute stroke. Stroke. 2010; 41:1978–1983.