Nat Prod Sci.
2020 Dec;26(4):303-310. 10.20307/nps.2020.26.4.303.
Calyxaprenols A-D, New Merohexaprenoid Metabolites from the Marine Sponge Calyx sp.
- Affiliations
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- 1Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA, 21702-1201
- KMID: 2511949
- DOI: http://doi.org/10.20307/nps.2020.26.4.303
Abstract
- Four new merohexapenoids named calyxaprenols A-D (1 - 4), together with the known compound haliclotriol A (5), have been isolated from the marine sponge Calyx sp. which was collected from the southwest islands of Palau. Based on comprehensive spectroscopic analyses, calyxaprenols A (1) and B (2) were determined to be pentacyclic hexaprenoids that are appended to a glycolic acid-substituted phenol moiety, whereas calyxaprenols C (3) and D (4) possess a tricyclic hexaprenoid skeleton joined to a hydroquinone ring. Identification of new merohexaprenoids from a Calyx sponge expands the known taxonomic distribution of this sparsely distributed class of marine metabolites and increases the chemical diversity described for this genus of marine sponge.
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