J Mycol Infect.
2020 Mar;25(1):10-16. 10.17966/JMI.2020.25.1.10.
A Multicenter Study of Antifungal Use and Species Distribution and Antifungal Susceptibilities of Candida Isolates in South Korea
- Affiliations
-
- 1Department of Laboratory Medicine, Chonnam National University Medical School, Gwangju, Korea
- 2Department of Parasitology and Tropical Medicine, Chonnam National University Medical School, Gwangju, Korea
- 3Department of Microbiology, Chonnam National University Medical School, Gwangju, Korea
- 4Department of Laboratory Medicine, Gyeongsang National University School of Medicine, Jinju, Korea
- 5Department of Laboratory Medicine, National Health Insurance Service Ilsan Hospital, Goyang, Korea
- 6Department of Laboratory Medicine, Pusan National University School of Medicine, Pusan National University Hospital, Busan, Korea
- 7Department of Laboratory Medicine, Inje University College of Medicine, Busan, Korea
- 8Department of Laboratory Medicine, Chungbuk National University College of Medicine, Cheongju, Korea
- 9Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul, Korea
- KMID: 2511716
- DOI: http://doi.org/10.17966/JMI.2020.25.1.10
Abstract
- Background
Candidiasis control should include monitoring the epidemiology and resistance to various antifungal agents. In this study, the researchers investigated the Candida species recovered from clinical specimens at particular geographic areas or hospitals.
Objective
The present study is geared toward the evaluation of antifungal drug usage at Korean hospitals in 2016. It is also essential that species distribution and antifungal susceptibilities of Candidaisolates should be looked into to provide important data that can help devise therapeutic strategies to control the disease.
Methods
Systemic antifungal agent usage over a one-year period was investigated at 10 Korean hospitals. Identification and antifungal susceptibility tests were performed on clinical isolates of the Candida species, which were collected over a three-month period.
Results
The total antifungal usage in each hospital ranged from 7.7 to 158.9 defined daily doses (DDDs) per 1,000 patient days. Fluconazole was most commonly used (37.1%), followed by amphotericin B (30.6%), itraconazole (9.7%), echinocandins (8.8%), voriconazole (7.5%), and posaconazole (6.3%), respectively. Among 274 Candida isolates, C. albicans was the most frequently recovered (51.1%), followed by C. glabrata (15.7%), C. tropicalis (15.0%), and C. parapsilosis (13.5%), respectively. Through the application of either species-specific clinical breakpoints or epidemiological cutoff values to Candida isolates, the non-susceptibility rates to fluconazole, voriconazole, amphotericin B, and micafungin were found in 20.7%, 5.6%, 0%, and 0% of isolates, respectively.
Conclusion
This nationwide multicenter study showed that total antifungal use varied considerably according to each hospital. Non-susceptibility to fluconazole should be further monitored, considering the drug's frequent use in Korea.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Antifungal Drug Susceptibility
- Species Distribution and Antifungal Susceptibilities of Yeast Clinical Isolates from Three Hospitals in Korea, 2001 to 2007
- Antifungal Susceptibility Testing with Etest for Candida Species Isolated from Patients with Oral Candidiasis
- Species Distribution and Susceptibilities to Azoles of Candida Species Including C. tropicalis in a Tertiary Burn Center
- Antifungal Susceptibility Testing of Candida Species Using ATB FUNGUS 2
