Psychiatry Investig.  2021 Jan;18(1):11-18. 10.30773/pi.2020.0205.

The Association of Blood-Based Inflammatory Factors IL-1β, TGF-β and CRP with Cognitive Function in Alzheimer’s Disease and Mild Cognitive Impairment

• Park JK
• Lee KJ
• Kim JY
• Kim H

• KMID: 2511575
• DOI: http://doi.org/10.30773/pi.2020.0205

Abstract

Objective
Many patients suffer from dementia in its most common form, Alzheimer’s disease (AD). In this study, the levels of IL-1β, TGF-β and CRP, which are involved in the inflammatory response in Alzheimer’s disease and its mild cognitive impairment (MCI), were measured and analyzed.
Methods
Seventy nine subjects participated in this study (mean age: 75.56 years, female: 54.3%, AD: 26, MCI: 28, normal: 25). The overall cognitive function of the subjects and the severity of the disease stage were assessed using the Mini-Mental State Examination (MMSE-K), the Clinical Dementia Rating (CDR), the Global Deterioration Scale (GDS) and the Geriatric Depression Scale-Korean (GDS-K).
Results
It was observed that patients with AD had significantly higher levels of IL-1β and TGF-β than the patients with MCI and normal controls. In addition, the MCI group showed a statistically significantly higher TGF-β concentration than the normal group.
Conclusion
These results suggest that IL-1β and TGF-β may be useful biological markers for patients with Alzheimer’s disease.

Keyword

IL-1β, TGF-β, CRP, Alzheimer’s disease, Mild cognitive impairment