Chonnam Med J.  2021 Jan;57(1):27-35. 10.4068/cmj.2021.57.1.27.

Liposomes: Biomedical Applications

• Kim EM
• Jeong HJ

• KMID: 2510782
• DOI: http://doi.org/10.4068/cmj.2021.57.1.27

Abstract

Liposomes, with their flexible physicochemical and biophysical properties, continue to be studied as an important potential a critical drug delivery system. Liposomes have overcome the challenges of conventional free drug therapy by encapsulating therapeutic agents, thereby improving in vivo biodistribution and reducing systemic toxicity. New imaging modalities and interpretation techniques, as well as new techniques for targetable system formulation technique, and tumor environmental information, have affected the search for a means of overcoming the difficulties of conventional liposome formulation. In this review, we briefly discuss how liposomal formulation has been applied across the biomedical field, particularly as a therapy, and the role it may play in the future, when paired with new developments in diagnosis and theranostics. The biological challenges that still remain and the translational obstacles are discussed.

Keyword

Liposomes; Drug Delivery Systems; Precision Medicine; Neoplasms