J Korean Med Sci.  2021 Jan;36(2):e17. 10.3346/jkms.2021.36.e17.

The Importance of Early Recognition, Timely Management, and the Role of Healthcare Providers in Multisystem Inflammatory Syndrome in Children

  • 1Department of Pediatrics, College of Medicine, Chungbuk National University, Cheongju, Korea
  • 2Department of Pediatrics, Chungbuk National University Hospital, Cheongju, Korea
  • 3Department of Infection Control and Prevention, Chungbuk National University Hospital, Cheongju, Korea


In April 2020, a pediatric report of an unusual inflammatory illness associated with coronavirus disease 2019 (COVID-19) led to similar cases in Europe and North America, which was referred to as multisystem inflammatory syndrome in children (MIS-C). Herein, we describe the case of a 12-year-old boy who had a history of polymerase chain reactionconfirmed COVID-19 and developed MIS-C approximately three weeks after an initial diagnosis of COVID-19. High fever with abdominal pain mimicking appendicitis was the initial manifestation of MIS-C, which could have been easily missed if the patient's history of COVID-19 was ignored. Intravenous immunoglobulin was administered twice, 24 hours apart, five days after the onset of MIS-C, and the patient fully recovered without any obvious sequelae. Early recognition by disease awareness and prompt management are the keys to saving the lives of children affected by MIS-C.


COVID-19; Kawasaki Disease; Multisystem Inflammatory Syndrome in Children; SARS-CoV-2
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