World J Mens Health.
2021 Jan;39(1):99-106. 10.5534/wjmh.190121.
Hepatitis B Surface Antigen Seropositive Men in Serodiscordant Couples: Effects on the Assisted Reproductive Outcomes
- Cito G
1 - Coccia ME2
- Fucci R2
- Picone R2
- Cocci A1
- Sessa M3
- Sessa F1
- Rizzello F2
- Micelli E4
- Trotta M5
- Badolato L2
- Campi R1
- Criscuoli L2
- Serni S1
- Carini M1
- Natali A1
- Affiliations
-
- 1Department of Urology, Careggi Hospital, University of Florence, Florence, Italy.
- 2Assisted Reproductive Technology Centre, Careggi Hospital, University of Florence, Florence, Italy.
- 3Campania Pharmacovigilance and Pharmacoepidemiology Regional Centre, Department of Experimental Medicine, University of Campania “L. Vanvitelli”, Naples, Italy.
- 4Department of Gynecology and Obstetrics, St. Claire Hospital, University of Pisa, Pisa, Italy.
- 5Department of Critical Care Medicine and Surgery, Infectious Disease Unit, Careggi Hospital, University of Florence, Florence, Italy.
- KMID: 2509585
- DOI: http://doi.org/10.5534/wjmh.190121
Abstract
- Purpose
To evaluate the influence of hepatitis B virus (HBV) infection in men of serodiscordant couples on the reproductive outcomes.
Materials and Methods
A total of 134 infertile couples were included in this retrospective single-center cohort study. Sixty-six couples had hepatitis B surface antigen (HBsAg)-seropositive men and seronegative partners, while 68 couples were controls with both seronegative men and women. Overall, 134 fresh in-vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) treatments were performed. As the main outcome measures, on the day of the fresh IVF/ICSI cycle, we assessed seminal parameters Before and after sperm preparation techniques. Two-pronuclear (2PN) fertilization, 1-2-3PN fertilization, cleavage, miscarriage, pregnancy and live birth rates were collected.
Results
No significant differences were found between groups in terms of oocytes retrieved, oocytes injected and embryos obtained (p=0.64, p=0.97, and p=0.40, respectively). The 2PN fertilization rate (FR) was comparable among groups (p=0.51). The 1-2-3PN FR was significantly lower in the HBsAg group than in the control group (66.6% vs. 69.7%, respectively). The clinical pregnancy per cycle, implantation, miscarriage and live birth rate were comparable between the HBsAg group and the control group. The median sperm concentration/ml and total sperm count, measured at baseline and after sperm preparation, was comparable between groups (p>0.05). There was a trend toward significant lower progressive motility (35.0% vs.55.0%; p<0.05) in the HBsAg group at baseline and after sperm preparation (p<0.05).
Conclusions
HBV infected men have the same chance to became father, compared to seronegative patients.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Prevalence of hepatitis B surface antigen in pediatric in patients
- The Eligibility Study of Anesthesia and Surgery for HBs Antigen Positive Patients
- Successful Pregnancy and Delivery with Intracytoplasmic Sperm Injection in HIV-Serodiscordant Couple: the First Case in Korea
- Growing attention to an old marker, hepatitis B surface antigen, in the natural history of chronic hepatitis B
- Staphylococcus saprophyticus and Escherichia coli: Tracking from sperm fertility potential to assisted reproductive outcomes
