Korean J Transplant.
2020 Dec;34(Supple 1):S57. 10.4285/ATW2020.OP-1182.
Serum antibody screening for non-human leukocyte antigen antibodies associated with antibody-mediate rejection reveals significance of anti-collagen type I and type III antibodies
- Affiliations
-
- 1Division of Nephrology, Department of Internal Medicine, Korean Armed Forces Capital Hospital, Seongnam, Korea
- 2Kidney Research Institute, Seoul National University Hospital, Seoul, Korea
- 3Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea
- 4Division of Transplantation, Department of Surgery, Seoul National University Hospital, Seoul, Korea
- 5Department of Pathology, Seoul National University Hospital, Seoul, Korea
- 6Department of Laboratory Medicine, Seoul National University Hospital, Seoul, Korea
- KMID: 2509202
- DOI: http://doi.org/10.4285/ATW2020.OP-1182
Abstract
- ackground: Additional study is warranted to determine the clinical significance of various non-human leukocyte antigen (HLA) antibodies on their association with the antibody-mediated rejection (ABMR) in kidney allografts.
Methods
The study included transplant recipients in one of the tertiary hospitals in Korea. We collected post-transplant sera from 68 ABMR, 67 T-cell mediated rejection (TCMR), and 83 controls without rejection cases and screened titers 39 non-HLA antibodies. We compared the non-HLA antibody titers among the study groups. We investigated their association with the risk of death-censored graft failure within the ABMR cases.
Results
The ABMR cases were diagnosed in later periods from transplantation and had a higher proportion of HLA-mismatched or HLA donor-specific antibody (DSA) positive cases when compared to the controls. Among the measured antibodies, anti-collagen type I (P=0.001) and type III antibody (P<0.001) titers were significantly higher in the ABMR cases when compared to the TCMR or no rejection controls. The both titers of anti-collagen type I (per 1 standard deviation [SD]; adjusted odds ratio [OR], 10.45; 95% confidence interval [CI], 2.52–66.62) and type III (per 1 SD; adjusted OR, 5.88; 95% CI, 1.84–28.98) antibody were significantly associated with presence of ABMR even after adjusting the presence of HLA-DSAs or other clinicopathologic findings. Within the ABMR group, a higher titer of anti-collagen type I (adjusted hazard ratio [HR], 1.82; 95% CI, 1.28–2.58) or type III (adjusted HR, 1.53; 95% CI, 1.14–2.07) antibody was associated with higher risk of death-censored graft failure.
Conclusions
Post-transplant anti-collagen I and collagen III antibodies may be novel non-HLA antibodies that are related to ABMR of kidney allografts.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Association of preoperative non-HLA antibodies with kidney allograft rejection
- Preexisting nonhuman leukocyte antigen antibodies are associated with allograft rejection after thoracic transplantation
- Fibronectin, Type IV Collagen, and Concanavalin A in Human Bruch's Membrane
- Immunogold Localization of Type VII Collagen in the Adhesion Complex of Pathologic Cornea
- Investigation of non-human leukocyte antigen antibodies and epitope mismatch in kidney transplant recipients with chronic antibody-mediated rejection
