Korean J Transplant.  2020 Dec;34(Supple 1):S51. 10.4285/ATW2020.OR-1086.

Retroperitoneal Viscum album extract injection in high drain output patient after renal transplantation

• Park Y
• Kim M
• Jun K
• Hwang J
• Kim S
• Park S
• Kim J
• Yoon S
• Moon I

• KMID: 2509192
• DOI: http://doi.org/10.4285/ATW2020.OR-1086

Abstract

Background
After renal transplantation, high drain output of lymph fluid is one of the causes of delaying postoperative recovery with longer hospital stay. Viscum albumextract (sold under the brand name Helixor M) is one of the agents used in pleurodesis procedure when treating malignant pleural effusion, and we evaluated efficacy of this agent in reducing drainage volume and incidence of lymphocele after renal transplantation.
Methods
We retrospectively reviewed medical records of patients with high drain output (>100 mL at postoperative day [POD] 7) after renal transplantation who undergone Viscum album extract injection via drain (n=23) or conservative care (n=23). The primary end point is reduced volume in drain output at POD 14 from POD 7. The secondary end point was postoperative recovery as reflected by the duration of hospitalization and incidence of lymphocele during 3 months after operation.
Results
Reduction in drain output at POD 14 from POD 7 was larger in the Viscum albumextract injection group than in the conservative care group (226.5 mL vs. 83.3 mL; P=0.010). Duration of hospitalization after operation was shorter in the Viscum albumextract injection group than in the conservative care group (16.0 days vs. 19.5 days; P=0.012). Ratio of patients who discharge with drain kept was also less in the Viscum album extract injection group than in the conservative care group (17.4% vs. 52.2%; P=0.029).
Conclusions
In this study, reduction in drain output at POD 14 from POD 7 was larger and duration of hospitalization was shorter after renal transplantation when Viscum album extract was injected via drain, suggesting that Viscum album extract injection could be considered for faster postoperative recovery in high drain output patients after renal transplantation.