J Rheum Dis.  2020 Oct;27(4):277-284. 10.4078/jrd.2020.27.4.277.

Association Between Signal Transducers and Activators of Transcription 4 rs7574865 Polymorphism and Systemic Lupus Erythematosus: A Meta-analysis

Affiliations
  • 1Department of Rheumatology, Korea University College of Medicine, Seoul, Korea

Abstract


Objective
. The purpose of this study was to determine whether the rs7574865 polymorphism of signal transducers and transcription 4 activators (STAT4) in multiple ethnic populations is associated with susceptibility to systemic lupus erythematosus (SLE). Methods. A meta-analysis on the STAT4 T allele rs7574865 polymorphism was performed in all subjects of study as well as in each ethnic population. Results. It included twenty-four manuscripts with 36 comparative studies of 22,898 SLE patients and 24,838 controls. The mean frequency of the STAT4 rs7574865 T allele was 28.5%, ranging from 14.3% to 35.7%, among the controls. T allele rates were 14.3%, 22.8%, 31.9%, 32.4%, and 35.7%, respectively in African American, European, Arab, Asian, and Latin American populations. Meta-analysis revealed a substantial correlation in all subjects between STAT4 rs7574865 and SLE (odds ratio=1.549, 95% confidence interval=1.459∼1.644, p<0.001). Analysis after stratification of race showed a strong association between the STAT4 rs7574865 T allele and SLE in Europeans, Asians, Latin Americans, African Americans, and Arabs. Conclusion. This meta-analysis demonstrated that the STAT4 rs7574865 polymorphism in different ethnic groups was correlated with SLE susceptibility, and that its prevalence depended on ethnicity.

Keyword

STAT4 transcription factor; Genetic polymorphism; Systemic lupus erythematosus; Meta-analysis

Figure

  • Figure 1 Odd ratio and 95% confidence interval (CI) of individual studies and pooled data for the association between the STAT4 rs7574865 polymorphism T allele and systemic lupus erythematosus (SLE) in all subjects.

  • Figure 2 Odd ratios and 95% confidence intervals (CIs) of individual studies and of pooled data for the association between the T allele and systemic lupus erythematosus (SLE) in each ethnic group.

  • Figure 3 Funnel plot of studies for the association between the T allele and systemic lupus erythematosus in all subjects (Egger’s regression p-value=0.614). Std err: standard error.


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