J Korean Diabetes.  2020 Mar;21(1):41-45. 10.4093/jkd.2020.21.1.41.

Nutrients and Diabetes Mellitus: Potassium

• Kang JH

• KMID: 2506773
• DOI: http://doi.org/10.4093/jkd.2020.21.1.41

Abstract

Potassium (K) is an essential mineral that plays major roles in intracellular osmolality and acid-base balance. In addition, potassium affects endothelial and vascular smooth muscle functions and has been shown to decrease blood pressure. Recently, potassium intake and plasma potassium concentration have been reported to be related to insulin secretion and diabetes risk. Therefore, in this article, we review how potassium intake reduces blood pressure and affects insulin release. We also determine methods for safe consumption and dose of potassium.

Keyword

Blood glucose; Blood pressure; Diabetes mellitus; Potassium

Reference

1. The Korean Nutrition Society. 2015 Dietary reference intake for Korean. Seoul: The Korean Nutrition Society;2015. p. 659–76.

2. He FJ, MacGregor GA. Potassium intake and blood pressure. Am J Hypertens. 1999; 12(8 Pt 1):849–51.

3. Chatterjee R, Yeh HC, Shafi T, Selvin E, Anderson C, Pankow JS, Miller E, Brancati F. Serum and dietary potassium and risk of incident type 2 diabetes mellitus: the Atherosclerosis Risk in Communities (ARIC) study. Arch Intern Med. 2010; 170:1745–51.

4. Shils ME, Shike M. Modern nutrition in health and disease. Baltimore, MD: Lippincott Williams & Wilkins;2006.

5. he Korean Society of Hypertension. 2018 Hypertension guideline. Seoul: The Korean Society of Hypertension;2018. p. 14–8.

6. Young DB, Lin H, McCabe RD. Potassium’s cardiovascular protective mechanisms. Am J Physiol. 1995; 268(4 Pt 2):R825–37.

7. Elford J, Phillips A, Thomson AG, Shaper AG. Migration and geographic variations in blood pressure in Britain. BMJ. 1990; 300:291–5.

8. Appel LJ, Moore TJ, Obarzanek E, Vollmer WM, Svetkey LP, Sacks FM, Bray GA, Vogt TM, Cutler JA, Windhauser MM, Lin PH, Karanja N. A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group. N Engl J Med. 1997; 336:1117–24.

9. Svetkey LP, Simons-Morton D, Vollmer WM, Appel LJ, Conlin PR, Ryan DH, Ard J, Kennedy BM. Effects of dietary patterns on blood pressure: subgroup analysis of the Dietary Approaches to Stop Hypertension (DASH) randomized clinical trial. Arch Intern Med. 1999; 159:285–93.

10. Stamler R. Implications of the INTERSALT study. Hypertension. 1991; 17(1 Suppl):I16–20.

11. Roger VL, Go AS, Lloyd-Jones DM, Benjamin EJ, Berry JD, Borden WB, Bravata DM, Dai S, Ford ES, Fox CS, Fullerton HJ, Gillespie C, Hailpern SM, Heit JA, Howard VJ, Kissela BM, Kittner SJ, Lackland DT, Lichtman JH, Lisabeth LD, Makuc DM, Marcus GM, Marelli A, Matchar DB, Moy CS, Mozaffarian D, Mussolino ME, Nichol G, Paynter NP, Soliman EZ, Sorlie PD, Sotoodehnia N, Turan TN, Virani SS, Wong ND, Woo D, Turner MB. Executive summary: heart disease and stroke statistics–2012 update: a report from the American Heart Association. Circulation. 2012; 125:188–97.

12. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, Jones DW, Materson BJ, Oparil S, Wright JT Jr, Roccella EJ. Seventh report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure. Hypertension. 2003; 42:1206–52.

13. Ekmekcioglu C, Elmadfa I, Meyer AL, Moeslinger T. The role of dietary potassium in hypertension and diabetes. J Physiol Biochem. 2016; 72:93–106.

14. Triplitt CL. Examining the mechanisms of glucose regulation. Am J Manag Care. 2012; 18(1 Suppl):S4–10.

15. Schmid D, Stolzlechner M, Sorgner A, Bentele C, Assinger A, Chiba P, Moeslinger T. An abundant, truncated human sulfonylurea receptor 1 splice variant has prodiabetic properties and impairs sulfonylurea action. Cell Mol Life Sci. 2012; 69:129–48.

16. Colditz GA, Manson JE, Stampfer MJ, Rosner B, Willett WC, Speizer FE. Diet and risk of clinical diabetes in women. Am J Clin Nutr. 1992; 55:1018–23.

17. Shin D, Joh HK, Kim KH, Park SM. Benefits of potassium intake on metabolic syndrome: The fourth Korean National Health and Nutrition Examination Survey (KNHANES IV). Atherosclerosis. 2013; 230:80–5.

18. Lee H, Lee J, Hwang SS, Kim S, Chin HJ, Han JS, Heo NJ. Potassium intake and the prevalence of metabolic syndrome: the Korean National Health and Nutrition Examination Survey 2008-2010. PLoS One. 2013; 8:e55106.

19. Azadbakht L, Mirmiran P, Esmaillzadeh A, Azizi T, Azizi F. Beneficial effects of a dietary approaches to stop hypertension eating plan on features of the metabolic syndrome. Diabetes Care. 2005; 28:2823–31.

20. Elliott WJ, Meyer PM. Incident diabetes in clinical trials of antihypertensive drugs: a network meta-analysis. Lancet. 2007; 369:201–7.

21. Houston MC. The effects of antihypertensive drugs on glucose intolerance in hypertensive nondiabetics and diabetics. Am Heart J. 1988; 115:640–56.