Korean J Dermatol.  2020 Sep;58(8):547-550.

Primary Cutaneous Nodular Amyloidosis in Both Lip Angles

  • 1Departments of Dermatology and Pathology 1 , Inha University School of Medicine, Incheon, Korea


Primary cutaneous nodular amyloidosis is a rare variant of primary cutaneous amyloidosis and manifests as nodular, light-chain, amyloid deposits that are localized to the skin. The pathogenesis of the disease is still unclear. It usually originates in the lower extremities, face, scalp, and genitals and presents clinically as waxy, yellowish erythematous colored nodules. Histological characteristics include diffuse homogenous eosinophilic deposits in the dermis or subcutaneous regions along with interspersed plasma cells. We report a case of a 72-year-old man who presented with fissured, erythematous, waxy nodules on the bilateral lip angles. To the best of our knowledge, this is the first case report of primary cutaneous nodular amyloidosis of the lip angles in Korean dermatological literature.


Primary; Nodular; Amyloidosis; Lip
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