Clin Psychopharmacol Neurosci.
2020 Aug;18(3):463-466. 10.9758/cpn.2020.18.3.463.
Immune Activation and Deficit in Neurotransmitters Synthesis in Treatment Resistant Depression: About a Case of Hashimoto Encephalopathy
- Ellul P
1,* - Gasnier M2,*
- Trebossen V1
- Gaillard R3,4
- Affiliations
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- 1Sorbonne Université, Assistance Publique-Hôpitaux de Paris (AP-HP), Robert Debré Hospital, Department of Child and Adolescent Psychiatry, Paris, France
- 2Assistance Publique-Hôpitaux de Paris (AP-HP), Hotel-Dieu, Unité de Psychiatrie, Paris, France
- 3Centre Hospitalier Sainte-Anne, Faculty of Medicine Paris Descartes, Service Hospitalo-Universitaire, Paris, France
- 4Université Paris Descartes, INSERM UMR S894, Centre de Psychiatrie et Neurosciences, Laboratoire de Physiopathologie des Maladies Psychiatriques, Paris, France
- KMID: 2505695
- DOI: http://doi.org/10.9758/cpn.2020.18.3.463
Abstract
- We report a case of Hashimoto encephalopathy initially presented as a drug-resistant depression with predominant apathy and asthenia, successfully treated with cyclophosphamide. We suspected that the psychiatric symptoms were due to a deficit in neurotransmitter synthesis related to immune activation. We hypothesized that the immunomodulatory treatment helped to restore the neurotransmitter synthesis and thus decreased the patient’s depressive symptoms. In this case report we propose an innovative model in which immunity might disturbs neurotransmitters synthesis leading to depressive symptoms.
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