J Rheum Dis.  2020 Jul;27(3):213-214. 10.4078/jrd.2020.27.3.213.

Ochronotic Spondyloarthropathy Mimicking Diffuse İdiopathic Skeletal Hyperostosis

• Uslu S

• KMID: 2504037
• DOI: http://doi.org/10.4078/jrd.2020.27.3.213

Figure

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  Figure 1 Photographs show blue-black pigmentation of the sclera (arrow) (A) and ear pinna (arrowhead) (B), X-ray of the thoracolumbar spine, multilevel intervertebral disc space narrowing associated with disc calcifications (C∼E). We received the patient’s consent form about publishing all photographic materials.

Reference

1. Phornphutkul C, Introne WJ, Perry MB, Bernardini I, Murphey MD, Fitzpatrick DL, et al. 2002; Natural history of alkaptonuria. N Engl J Med. 347:2111–21. DOI: 10.1056/NEJMoa021736. PMID: 12501223.

2. Ventura-Ríos L, Hernández-Díaz C, Gutiérrez-Pérez L, Bernal-González A, Pichardo-Bahena R, Cedeño-Garcidueñas AL, et al. 2016; Ochronotic arthropathy as a paradigm of metabolically induced degenerative joint disease. A case-based review. Clin Rheumatol. 35:1389–95. DOI: 10.1007/s10067-014-2557-7. PMID: 24647979.

3. Ranganath LR, Khedr M, Milan AM, Davison AS, Hughes AT, Usher JL, et al. 2018; Nitisinone arrests ochronosis and decreases rate of progression of Alkaptonuria: evaluation of the effect of nitisinone in the United Kingdom National Alkaptonuria Centre. Mol Genet Metab. 125:127–34. DOI: 10.1016/j.ymgme.2018.07.011. PMID: 30055994.

4. Toth K, Lenart E, Janositz G, Takacs K. 2003; Ochronotic arthropathy. Scand J Rheumatol. 32:315–7. DOI: 10.1080/03009740310003983. PMID: 14690148.