Kidney Res Clin Pract.  2020 Mar;39(1):60-69. 10.23876/j.krcp.19.077.

Patterns in renal diseases diagnosed by kidney biopsy: A single-center experience

• Yim T
• Kim SU
• Park S
• Lim JH
• Jung HY
• Cho JH
• Kim CD
• Kim YL
• Han MH
• Kim YJ
• Choi JY
• Park SH

• KMID: 2503741
• DOI: http://doi.org/10.23876/j.krcp.19.077

Abstract

Background
The worldwide incidence of renal disease diagnosed by a kidney biopsy varies with age, race, sex, and region. Owing to a lack of studies and limited research resources for this disease in Korea, we investigated renal disease patterns by analyzing data from kidney biopsies performed over 13 years in a university-based teaching hospital in Korea.
Methods
Among 2,053 kidney biopsies performed from 2001 to 2013 at Kyungpook National University Hospital, 1,924 were retrospectively analyzed for histopathologic, demographic, and clinical data as well as laboratory results.
Results
Among the 1,924 studied kidney biopsies, 1,078 were males (56.0%) and the mean age was 37.7 ± 16.5 years. Asymptomatic urinary abnormalities were the most common clinical manifestation (62.5%). Immunoglobulin A nephropathy (IgAN) was the most common primary glomerular disease (37.4%), followed by minimal change disease (MCD), membranous nephropathy (MN), focal segmental glomerulonephritis and crescentic glomerulonephritis. Secondary glomerular diseases accounted for 10.3% of the total biopsies, with lupus nephritis being the most common (4.6%) followed by Henoch-Schönlein purpura nephritis and diabetic nephropathy. The most common cause of nephrotic syndrome was MCD (42.1%) followed by MN. Among patients seropositive for hepatitis B or C, IgAN (28.3% and 21.4%, respectively) was the most common cause.
Conclusion
IgAN and lupus nephritis were the most common primary and secondary glomerular diseases, respectively. Race, region, and practice patterns may affect renal disease patterns in different cohorts.

Keyword

Biopsy; Glomerulonephritis; Kidney diseases; Nephrotic syndrome