Tuberc Respir Dis.  2020 Jul;83(3):248-254. 10.4046/trd.2020.0008.

Clinical Impact of Supplementation of Vitamins B1 and C on Patients with Sepsis- Related Acute Respiratory Distress Syndrome

Affiliations
  • 1Department of Internal Medicine, Gyeongsang National University Hospital, Jinju, Korea
  • 2Regional Cardiocerebrovascular Disease Center, Gyeongsang National University Hospital, Jinju, Korea
  • 3Gyeongsang National University School of Medicine, Jinju, Korea
  • 4Department of Internal Medicine, Gyeongsang National University Changwon Hospital, Changwon, Korea

Abstract

Background
Although few studies have reported improved clinical outcomes with the administration of vitamin B1 and C in critically ill patients with septic shock or severe pneumonia, its clinical impact on patients with sepsis-related acute respiratory distress syndrome (ARDS) remains unclear. The purpose of this study was to evaluate the association with vitamin B and C supplementation and clinical outcomes in patients with ARDS.
Methods
Patients with ARDS requiring invasive mechanical ventilation, admitted to the medical intensive care unit (ICU) were included in this study. Clinical outcomes were compared between patients administered with vitamin B1 (200 mg/day) and C (2 g/day) June 2018–May 2019 (the supplementation group) and those who did not receive vitamin B1 and C administration June 2017–May 2018 (the control group).
Results
Seventy-nine patients were included. Thirty-three patients received vitamin B1 and C whereas 46 patients did not. Steroid administration was more frequent in patients receiving vitamin B1 and C supplementation than in those without it. There were no significant differences in the mortality between the patients who received vitamin B1 and C and those who did not. There were not significant differences in ventilator and ICU-free days between each of the 21 matched patients.
Conclusion
Vitamin B1 and C supplementation was not associated with reduced mortality rates, and ventilator and ICU-free days in patients with sepsis-related ARDS requiring invasive mechanical ventilation.

Keyword

Sepsis; Acute Respiratory Distress Syndrome; Vitamin B1; Vitamin C
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