Ann Lab Med.  2020 Sep;40(5):431-434. 10.3343/alm.2020.40.5.431.

Successful Desensitization by Post-Centrifugal Plasma Filtration in Two Highly Sensitized Heart and Lung Transplant Recipients

• Lee HJ
• Shin KH
• Kim HH
• Je HG
• Kim D
• Cho WH
• Kim JS
• Lee SY
• Yeo HJ

• KMID: 2502577
• DOI: http://doi.org/10.3343/alm.2020.40.5.431

Figure

• 

  Fig. 1 Changes in DSAs with desensitization treatment. (A) A heart transplant recipient (Case 1, Table 1) with preformed DSAs and (B) a lung transplant recipient (Case 2, Table 1) who underwent desensitization before donor matching. Abbreviations: ATG, anti-thymocyte globulin; DSA, donor-specific antibody; IVIG, intravenous immunoglobulin; MFI, mean fluorescence intensity; PCPF, post-centrifugal plasma filtration; POD, postoperative day.

Reference

1. Al-Mohaissen MA, Virani SA. Allosensitization in heart transplantation: an overview. Can J Cardiol. 2014; 30:161–72.

2. Li F, Atz ME, Reed EF. Human leukocyte antigen antibodies in chronic transplant vasculopathy-mechanisms and pathways. Curr Opin Immunol. 2009; 21:557–62.

3. Colvin MM, Cook JL, Chang PP, Hsu DT, Kiernan MS, Kobashigawa JA, et al. Sensitization in heart transplantation: Emerging knowledge: A scientific statement from the American Heart Association. Circulation. 2019; 139:e553–78.

4. Colvin MM, Cook JL, Chang P, Francis G, Hsu DT, Kiernan MS, et al. Antibody-mediated rejection in cardiac transplantation: emerging knowledge in diagnosis and management: a scientific statement from the American Heart Association. Circulation. 2015; 131:1608–39.

5. Park BG. Desensitization in HLA incompatible transplantation. Korean J Blood Transfus. 2019; 30:1–14.

6. Jordan SC, Reinsmoen N, Lai CH, Vo A. Novel immunotherapeutic approaches to improve rates and outcomes of transplantation in sensitized renal allograft recipients. Discov Med. 2012; 13:235–45.

7. Patel J, Everly M, Chang D, Kittleson M, Reed E, Kobashigawa J. Reduction of alloantibodies via proteasome inhibition in cardiac transplantation. J Heart Lung Transplant. 2011; 30:1320–6.

8. Iyer HS, Jackson AM, Zachary AA, Montgomery RA. Transplanting the highly sensitized patient: trials and tribulations. Curr Opin Nephrol Hypertens. 2013; 22:681–8.