Korean J Intern Med.
2020 Jan;35(1):12-24. 10.3904/kjim.2019.271.
Roles of mast cells in rheumatoid arthritis
- Affiliations
-
- 1Division of Rheumatology, Department of Internal Medicine, Konkuk University Medical Center, Seoul, Korea
- 2Conversant Research Consortium in Immunologic Disease, College of Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul, Korea
- 3Division of Rheumatology, Department of Internal Medicine, Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, Korea
- KMID: 2501983
- DOI: http://doi.org/10.3904/kjim.2019.271
Abstract
- Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory arthritis, and the complex interaction and activation of innate and adaptive immune cells are involved in RA pathogenesis. Mast cells (MCs) are one of the tissue-resident innate immune cells, and they contribute to RA pathogenesis. In the present review, the evidence of the pathologic role of MC in RA is discussed based on human and animal data. In addition, the potential role of MC in RA pathogenesis and the research area that should be focused on in the future are suggested.
